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TranscriptomicsChromosome 11q and its association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer
Background: The amplification event occurring at chromosome locus 11q13, reported in several different cancers, includes a number of potential oncogenes. We have previously reported amplification of one such oncogene, CCND1, to be correlated with an adverse effect of tamoxifen in premenopausal breas...
ORGANISM(S): Homo sapiens 
2008-10-07 | E-GEOD-12759 | biostudies-arrayexpress
TranscriptomicsMapping barley genes to chromosome arms by transcript profiling of wheat-barley ditelosomic chromosome addition lines
We utilized the Barley1 Affymetrix GeneChip for comparative transcript analysis of Betzes barley, Chinese Spring wheat, and Chinese SpringM-bM-^@M-^SBetzes ditelosomic chromosome addition lines to physically map barley genes to their respective chromosome arm locations. We mapped barley genes to ch...
ORGANISM(S): Triticum aestivum 
2011-11-22 | E-GEOD-33400 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchial epithelial cells overexpressing the lung developmental transcription factors TTF1, NKX2-8 and PAX9
We investigated the clinical implications of lung developmental transcription factors (TTF-1, NKX2-8, and PAX9) which we recently discovered as cooperating oncogenes activated by way of gene amplification at chromosome 14q13 in lung cancer. Using stable transfectants of human bronchial epithelial ce...
ORGANISM(S): Homo sapiens 
2009-04-10 | E-GEOD-9212 | biostudies-arrayexpress
TranscriptomicsChromosome 8 BAC Array CGH and Expression Studies Identify Amplification and Overexpression of TRMT12 in Breast Cancer
Genomic changes in chromosome 8 are commonly observed in breast cancer cell lines and tumors. Fine mapping of such genomic changes, and evaluation of associated expression changes, are expected to provide reagents for diagnosis, insights into understanding the disease, and open up avenues for novel ...
ORGANISM(S): Homo sapiens 
2007-05-07 | GSE6567 | GEO
TranscriptomicsInteractions among Polycomb domains are guided by chromosome architecture
Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes. Here, we adapted the Chromosome Conformation Capture on Chip (4C) assay to systematically map chromosomal in...
ORGANISM(S): Drosophila melanogaster 
2011-05-09 | E-GEOD-23166 | biostudies-arrayexpress
ProteomicsChromosome 8 gain drives cancer progression by hijacking the translational regulator 4E-BP1 sensitizing for targeted CDK4/6 inhibition
Chromosome 8 (chr8) gains are common in cancer. However, their potential contribution to tumor heterogeneity is largely unexplored. Ewing sarcoma (EwS) is characterized by pathognomonic FET::ETS fusions but a general paucity of other recurrent somatic mutations that could explain the observed clinic...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-09-22 | PXD065282 | Pride
Chromosome 8 gain 4e-bp1 ewing sarcoma Cdk4/6 inhibitor Chromosome 8 amplification Chromosome 8 copy number variation Eif4ebp1 
GenomicsGain and/or amplification of chromosome 1q are frequently found in Multiple Myeloma (MM).
Gain and/or amplification of chromosome 1q are frequently found in Multiple Myeloma (MM).
PRJNA796206 | ENA
TranscriptomicsGenome position and gene amplification - expressional profiling of methotrexate resistant colonies
We investigated the influence of genome position on propensity to amplify. First, we integrated a mutant form of DHFR into different positions in the human genome, challenged cells with methotrexate and then studied the genomic alterations arising in drug resistant cells. We observed site specific d...
ORGANISM(S): Homo sapiens 
2007-10-08 | E-GEOD-6361 | biostudies-arrayexpress
GenomicsThe inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.
3D-topology of DNA in the cell nucleus provides a level of transcription regulation beyond the sequence of the linear DNA. To study the relationship between transcriptional activity and spatial environment of a gene, we have used allele-specific 4C-technology to produce high-resolution topology maps...
ORGANISM(S): Mus musculus 
2011-06-24 | E-GEOD-29509 | biostudies-arrayexpress
TranscriptomicsLoss of DNA replication control is a potent initiator of gene amplification
Eukaryotic cells use numerous mechanisms to ensure that no segment of their DNA is re-replicated within a single cell cycle. Despite longstanding speculation that such tight regulation is needed to protect cells from genomic alterations, this notion has never been experimentally tested. Here we show...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-17 | E-GEOD-22018 | biostudies-arrayexpress
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