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UnknownA genome-wide linkage screen in the Amish with Parkinson disease points to chromosome 6.
Not available
S-EPMC3077806 | biostudies-literature
TranscriptomicsAn RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity, Experiment B
Proper regulation of chromatin structure is necessary for the maintenance of cell type-specific gene expression patterns. The embryonic stem cell (ESC) expression pattern governs self-renewal and pluripotency. Here, we present an RNAi screen in mouse ESCs of 1008 loci encoding chromatin proteins. We...
ORGANISM(S): Mus musculus 
2008-07-11 | E-GEOD-11241 | biostudies-arrayexpress
ProteomicsA functional genomics screen identifies genes required for Schizosaccharomyces pombe meiosis
Meiosis is a specialized cell division that generates gametes, such as eggs and sperm. Errors in meiosis result in miscarriages and are the leading cause of birth defects, however the molecular origins of these defects remain unknown. Studies in model organisms are beginning to identify the genes an...
ORGANISM(S): Schizosaccharomyces pombe 
2018-01-04 | PXD008245 | Pride
Schizosaccharomyces pombe Chromosome segregation Sporulation Meiosis 
GenomicsA high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2’-dC upon inhibition of ribonucleotide reductase-wide
Background: DNA methylation is important for maintenance of the silent state of genes on the inactive X chromosome (Xi). Here, we screened for siRNAs and chemicals that reactivate an Xi-linked reporter in the presence of 5-aza-2’-deoxycytidine (5-aza-2’-dC), an inhibitor of DNA methyltransferase 1, ...
ORGANISM(S): Homo sapiens 
2015-08-25 | E-GEOD-72295 | biostudies-arrayexpress
GenomicsA high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2’-dC upon inhibition of ribonucleotide reductase-wide
A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2’-dC upon inhibition of ribonucleotide reductase-wide
PRJNA293678 | ENA
TranscriptomicsCombined arrayCGH and SNP-loss of heterozygosity analysis in cervical cancer
BACKGROUND: Cervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mCGH) and microsatellite marker analysis for the detection of loss of heterozygos...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-8605 | biostudies-arrayexpress
UnknownGenome-wide mapping of susceptibility to coronary artery disease identifies a novel replicated locus on chromosome 17.
Not available
S-EPMC1463045 | biostudies-literature
TranscriptomicsshRNA cassette sequencing from disomic and trisomic fibroblasts cultured in the presence of shRNA kinome library for 14 days
Kinome-wide shRNA screen to identify kinases differentially required for survival of cells disomic and trisomic for chromosome 21 Cells were transduced in triplicate and propagated for 14 days to allow for enrichement or depletion of shRNAs from the population
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-79840 | biostudies-arrayexpress
TranscriptomicsRNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukemia
Epigenetic pathways regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. While chromatin alterations are...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-29799 | biostudies-arrayexpress
TranscriptomicsSystematic identification of balanced transposition polymorphisms in Saccharomyces cerevisiae
High-throughput techniques for detecting DNA polymorphisms generally do not identify changes in which the genomic position of a sequence, but not its copy number, varies among individuals. To explore such balanced structural polymorphisms, we used array-based Comparative Genomic Hybridization (aCGH)...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-19 | E-GEOD-14223 | biostudies-arrayexpress
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