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TranscriptomicsTranscription profiling of mouse brain after twelve week treatment with the antipsychotics Clozapine and Haloperidol
Atypical antipsychotic Clozapine has a superior antipsychotic and antimanic effects compared to other antisphicotics. Its widespread use was limited by the side effects of agranulocytosis, cardiomyopathy and metabolic anomalies such as weight gain, and diabetes. Very little is known about mechanisms...
ORGANISM(S): Mus musculus 
2009-02-07 | E-GEOD-6467 | biostudies-arrayexpress
ProteomicsChronic haloperidol treatment leads to an imbalance of synaptic excitation and inhibition of D1-MSN neurons pointing to a slow remodelling process
Schizophrenia is a chronic mental illness that is among the world’s top twenty causes of years lost to disability according to the global burden of disease 2019 (10.1016/S0140-6736(20)30925-9). Positive symptoms, including hallucinations and delusions in schizophrenia, often improved with convention...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD038471 | Pride
Msn Haloperidol Proteomics 
Proteomicsproteome and pathway effects of chronic haoperidol treatment in mouse hippocampus
Seven male C57BL/6 mice, at 10 weeks of age, were injected daily intraperitoneally with 0.5 mg/kg of haloperidol, for 28 days. A control group of six animals was injected with vehicle only (saline).
ORGANISM(S): Mus musculus (Mouse) 
2015-11-30 | PXD002250 | Pride
Chronic haloperidol treatment Mouse hippocampus Antipsychotics 
TranscriptomicsTranscription profiling of mouse brain from animals treated for 4 weeks with the antipsychotics Clozapine and Haloperidol
Atypical antipsychotic Clozapine has a superior antipsychotic and antimanic effects compared to other antisphicotics. Its widespread use was limited by the side effects of agranulocytosis, cardiomyopathy and metabolic anomalies such as weight gain, and diabetes. Very little is known about mechanisms...
ORGANISM(S): Mus musculus 
2009-04-30 | E-GEOD-6511 | biostudies-arrayexpress
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Human UPLC-MS/MS assays)

Progressive decline in lung function is a hallmark of chronic obstructive pulmonary disease (COPD). Although airway dysbiosis occurs in COPD, whether it contributes to disease progression remains unknown. Here, through a longitudinal analysis on 181 COPD individuals from two large cohorts involvi...

2023-06-12 | MTBLS5423 | MetaboLights
MetabolomicsResearch on the microbiota and metabolic characteristics of type 2 chronic rhinosinusitis based on the analysis of 16S amplicon sequencing combined with metabolomics

Objective:

To investigate the diversity of nasal microbiota and metabolic characteristics of patients with Type 

2 chronic rhinosinusitis, as well as the interactions and potential regulatory relationships between 

the nasal microbiota and their metabolites by conducti...

2025-10-21 | MTBLS13192 | MetaboLights
TranscriptomicsChronic haloperidol effects on gene expression in mouse [array]
We evaluate the effects of chronic administration of antipsychotic haloperidol versus placebo in male, 8-week old, C57BL/6J mice. We used microarray to study gene expression changes after haloperidol treatment in mouse brain and liver
ORGANISM(S): Mus musculus 
2016-04-10 | GSE67753 | GEO
TranscriptomicsTranscription profiling of mouse brain treated with clozapine and haloperidol
This SuperSeries is composed of the following subset Series:; GSE6467: Twelve weeks expression data of the antipsychotics Clozapine and Haloperidol in the mouse brain (Affymetrix, GCRMA). GSE6511: Four weeks expression data of the antipsychotics Clozapine and Haloperidol in the mouse brain (Affymetr...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6512 | biostudies-arrayexpress
TranscriptomicsUnique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control
Quetiapine is an atypical neuroleptic with a pharmacological profile distinct from classic neuroleptics. It is currently approved for treating patients with schizophrenia, major depression and bipolar I disorder. However, its cellular effects remain elusive. We used microarrays to characterize RNA t...
ORGANISM(S): Mus musculus 
2013-04-16 | E-GEOD-45229 | biostudies-arrayexpress
GenomicsMus musculus
Chronic haloperidol effects on gene expression in mouse [array]
PRJNA280829 | ENA
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