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TranscriptomicsTranscription profiling of mouse brain after twelve week treatment with the antipsychotics Clozapine and Haloperidol
Atypical antipsychotic Clozapine has a superior antipsychotic and antimanic effects compared to other antisphicotics. Its widespread use was limited by the side effects of agranulocytosis, cardiomyopathy and metabolic anomalies such as weight gain, and diabetes. Very little is known about mechanisms...
ORGANISM(S): Mus musculus 
2009-02-07 | E-GEOD-6467 | biostudies-arrayexpress
ProteomicsLRRK2 mediates haloperidol-induced changes in striatal indirect pathway circuits
Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2Rs that are highly expressed in the striatum. Significant side effects of haloperidol, known as extrapyramidal symptoms, lead to motor deficits similar to those...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-25 | PXD053892 | Pride
Striatal Haloperidol Lrrk2 
TranscriptomicsTranscription profiling of mouse brain from animals treated for 4 weeks with the antipsychotics Clozapine and Haloperidol
Atypical antipsychotic Clozapine has a superior antipsychotic and antimanic effects compared to other antisphicotics. Its widespread use was limited by the side effects of agranulocytosis, cardiomyopathy and metabolic anomalies such as weight gain, and diabetes. Very little is known about mechanisms...
ORGANISM(S): Mus musculus 
2009-04-30 | E-GEOD-6511 | biostudies-arrayexpress
ProteomicsChronic haloperidol treatment leads to an imbalance of synaptic excitation and inhibition of D1-MSN neurons pointing to a slow remodelling process
Schizophrenia is a chronic mental illness that is among the world’s top twenty causes of years lost to disability according to the global burden of disease 2019 (10.1016/S0140-6736(20)30925-9). Positive symptoms, including hallucinations and delusions in schizophrenia, often improved with convention...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD038471 | Pride
Msn Haloperidol Proteomics 
TranscriptomicsTranscription profiling of mouse brain treated with clozapine and haloperidol
This SuperSeries is composed of the following subset Series:; GSE6467: Twelve weeks expression data of the antipsychotics Clozapine and Haloperidol in the mouse brain (Affymetrix, GCRMA). GSE6511: Four weeks expression data of the antipsychotics Clozapine and Haloperidol in the mouse brain (Affymetr...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6512 | biostudies-arrayexpress
TranscriptomicsEffects of haloperidol on zebrafish and fathead minnow gene expression
This SuperSeries is composed of the following subset Series: GSE14861: Small_fish_comp_tox_ZF_haloperidol_96_h_ovary GSE15115: Small_fish_comp_tox_FHM_haloperidol_96_h_ovary Refer to individual Series
ORGANISM(S): Pimephales promelas 
2010-05-17 | E-GEOD-15216 | biostudies-arrayexpress
Proteomicsproteome and pathway effects of chronic haoperidol treatment in mouse hippocampus
Seven male C57BL/6 mice, at 10 weeks of age, were injected daily intraperitoneally with 0.5 mg/kg of haloperidol, for 28 days. A control group of six animals was injected with vehicle only (saline).
ORGANISM(S): Mus musculus (Mouse) 
2015-11-30 | PXD002250 | Pride
Chronic haloperidol treatment Mouse hippocampus Antipsychotics 
TranscriptomicsHaloperidol response across genetic backgrounds
We performed short-term bi-directional selective breeding for haloperidol-induced catalepsy, starting from three mouse populations of increasingly complex genetic structure: an F2 intercross, a heterogeneous stock (HS) formed by crossing four inbred strains (HS4) and a heterogeneous stock (HS-CC) fo...
ORGANISM(S): Mus musculus 
2012-05-05 | E-GEOD-37755 | biostudies-arrayexpress
TranscriptomicsUnique pharmacological actions of atypical neuroleptic quetiapine: possible role in cell cycle/fate control
Quetiapine is an atypical neuroleptic with a pharmacological profile distinct from classic neuroleptics. It is currently approved for treating patients with schizophrenia, major depression and bipolar I disorder. However, its cellular effects remain elusive. We used microarrays to characterize RNA t...
ORGANISM(S): Mus musculus 
2013-04-16 | E-GEOD-45229 | biostudies-arrayexpress
GenomicsTranscriptome profiling of haloperidol treated mouse bone marrow LSK cells
Transcriptome profiling of haloperidol treated mouse bone marrow LSK cells
PRJNA521347 | ENA
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