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Striatal medium spiny neurons (MSN) are critically involved in motor control, and their degeneration is a principal component of Huntington’s disease. We find that the transcription factor Ctip2 (also known as Bcl11b) is central to MSN differentiation and striatal development. Within the striatum,...
ORGANISM(S): Mus musculus 
Neurospora crassa FGSC 4200 knockout Gene Expression Profiling - msn-1 transcriptome
Here, we present a novel trioxane-based MS-cleavable homotrifunctional cross-linker TSTO, which can target three proximal lysine residues simultaneously. Owing to its unique structure and MS-cleavability, TSTO enables fast and unambiguous identification of cross-linked peptides using LC-MSn analysis...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-30 | PXD063825 | Pride
Peptide drugs have revolutionized modern medicine owing to their high potency, selectivity, and excellent tolerability. However, oral delivery remains limited, and most peptide drugs are administered parenterally due to their inherent instability to proteolytic digestion and poor ability to cross ga...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD074176 | Pride
Bipolar disorder (BPD) is a debilitating heritable psychiatric disorder. Contemporary models for the manic pole of BPD have primarily utilized either single locus transgenics or treatment with psychostimulants. Our lab recently characterized a mouse strain, termed Madison (MSN), which naturally di...
ORGANISM(S): Mus musculus 
Investigating the Impact of Genetic MSN Depletion on Gene Expression in MDA-MB-231 Breast Cancer Cells
Neurospora crassa FGSC 4200 msn-1-2 Gene Expression Profiling transcriptome
Neurospora crassa FGSC 4200 msn-1-3 Gene Expression Profiling transcriptome
The Transcription Factor Zfp503 Promotes the D1 MSN Identity and Represses the D2 MSN Identity
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