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TranscriptomicsEffects of chronic hypoxia on Duchenne Muscular Dystrophy Drosophila melanogaster model
In order to understand the chronic hypoxia (CH) effect upon the absence of dystrophin, Drosophila melanogaster wild type and the model for DMD (dmDys), in which all dystrophins expression was knocked out by iRNA, were exposed to high altitude hypoxia (hypobaric hypoxia) during a 16-day climbing per...
ORGANISM(S): Drosophila melanogaster 
2010-07-31 | E-GEOD-15879 | biostudies-arrayexpress
TranscriptomicsPhysiologic Hypoxia Promotes Maintenance of CML Stem Cells Despite Effective BCRM-bM-^HM-^RABL1 Inhibition
ABL1 kinase inhibitors such as imatinib mesylate (IM) are effective in managing chronic myelogenous leukemia (CML) but incapable of eliminating leukemia stem cells (LSCs), suggesting that kinaseM-bM-^HM-^Rindependent pathways support LSC survival. Given that the bone marrow hypoxic microenvironment ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-48294 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile in Developing Mouse Brain Following Chronic Hypoxia Treatment
In this study, we determined the effect of chronic consistent hypoxia (CCH) and chronic intermittent hypoxia (CIH) on global gene expression in cortical and hippocampal region of developing mouse brain using long-oligo beadschip arrays. Keywords: Gene expression profile Control-Cortex: Cortical samp...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-8262 | biostudies-arrayexpress
ProteomicsIn-depth Proteomics and Phosphoproteomics Reveal Biomarkers and Molecular Pathways of Chronic Intermittent Hypoxia in Mice
Obstructive sleep apnea (OSA) syndrome is characterized by Chronic Intermittent Hypoxia (CIH). In this study, we employed Data-independent acquisition (DIA) Mass Spectrometry to conduct comprehensive proteomic and phosphoproteomic profiling of a murine model subjected to Chronic Intermittent Hypoxia...
ORGANISM(S): Homo Sapiens 
PXD053746 |
TranscriptomicsGene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia
Chronic constant hypoxia (CCH), such as in pulmonary diseases or high altitude, and chronic intermittent hypoxia (CIH), such as in sleep apnea, can lead to major changes in the heart. The molecular mechanisms underlying these cardiac alterations are not well understood. We hypothesized that analysis...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2271 | biostudies-arrayexpress
TranscriptomicsComparative SAGE Analysis of the Response to Hypoxia in Human Pulmonary and Aortic Endothelial Cells
Cultures of human aortic (HAEC) and pulmonary artery endothelial cells (HPAEC) were exposured to short-term chronic hypoxia (1% O2) for either 0h, 8h or 24h Keywords: Time course, cell-type comparison The response of each cell type (HAEC and HPAEC) to short-term chronic hypoxia was determined by a s...
ORGANISM(S): Homo sapiens 
2005-06-28 | E-GEOD-2838 | biostudies-arrayexpress
ProteomicsAdaptation of Burkholderia cenocepacia to low oxygen drives changes consistent with adaptation to chronic infection.
Cystic fibrosis (CF) is characterised by chronic respiratory infections, involving opportunistic pathogens, including Burkholderia cenocepacia. The CF lung comprises hypoxic niches that drives bacterial adaptation and the adaptability of pathogens to this environment is key to their successful colon...
ORGANISM(S): Burkholderia cenocepacia J2315 Bacteria 
2026-01-19 | PXD067828 | Pride
Chronic infection Chronic lung disease. Cystic fibrosis Burkholderia cenocepacia Hypoxia Bacterial adaptation 
TranscriptomicsChronic Hypoxia predicts Poor Prognosis in Hepatocellular Carcinoma
Background - Hepatocellular carcinomas (HCCs) are heterogeneous tumors with respect to etiology, cell of origin and biology. The course of the disease is unpredictable and is in part dependent on the tumor microenvironment. One of the microenvironmental factors is hypoxia, which is known to promote ...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-15366 | biostudies-arrayexpress
TranscriptomicsTempO-Seq of human breast cancer MCF-7 and HCC1143 cell lines under chronic normoxia and hypoxia
Comparison of luminal and basal breast cancer cells under chronic normoxia and hypoxia. Cells were plated in 96-well plates and incubated 5 days under normoxia or hypoxia after which the wells were washed once with cold PBS and lysed using TempO-Seq lysis buffer for 15 min at room temperature. Sampl...
ORGANISM(S): Homo sapiens 
2023-06-01 | E-MTAB-12233 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of response to chronic constant hypoxia in adult Zebrafish hearts
Gene expression profile of the response to chronic constant hypoxia in the heart of adult zebrafish Experiment Overall Design: 10 arrays (5 for hypoxia and 5 normoxia); in total 8 biological samples plus 2 technical replicates
ORGANISM(S): Danio rerio 
2007-10-25 | E-GEOD-4989 | biostudies-arrayexpress
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