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TranscriptomicsTranscription profiling of mouse mammary gland gene expression and tumor growth following chronic social isolation
Clinical studies have revealed that social support improves the outcome of cancer patients while epidemiological studies suggest that social isolation increases the risk of death associated with several chronic diseases. However, the precise biological consequences of an unfavorable social environme...
ORGANISM(S): Mus musculus 
2009-07-11 | E-GEOD-16110 | biostudies-arrayexpress
ProteomicsPrefrontal cortical synaptoproteome profile combined with machine learning predict resilience towards chronic social isolation in rats
Chronic social isolation (CSIS), an animal model of depression, generates two stress-response phenotypes: CSIS-resilient and CSIS-susceptible. However, the molecular mechanism underlying resilience to CSIS remains unclear. We aimed to investigate the prefrontal cortical synaptoproteome profile betwe...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-04-23 | PXD047159 | Pride
Resilience Prefrontal cortex Proteomics Machine learning Chronic social isolation Synaptosome 
GenomicsGene Expression Changes during Chronic Social Isolation in Drosophila melanogaster
Gene Expression Changes during Chronic Social Isolation in Drosophila melanogaster
PRJNA565734 | ENA
TranscriptomicsTranscription profiling of rat nucleus accumbens shell shows CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits
We are comparing the gene expression patterns from rats in which they are either double housed or socially isolated. Within these groups we performed the following manipulations:

AAV-GFP to the NAc shell

AAV-CREB to the NAc shell

chronic imipramine treatment

water contro...
ORGANISM(S): Rattus norvegicus 
2009-01-01 | E-MEXP-1944 | biostudies-arrayexpress
ProteomicsHippocampal synaptoproteomic changes of susceptibility and resilience of rats to chronic social isolation
The susceptibility to chronic social isolation (CSIS) is associated with development of major depression (MD). Recent studies relate MD with altered expression of synaptic proteins in specific brain regions, whereby some individuals exposed to the stressors are resistant to the stress. To explore th...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-11-27 | PXD019790 | Pride
Synaptosomal fraction Rat Hippocampus Proteomics Lc-ms/ms 
TranscriptomicsTranscription profiling of mouse liver from animals exposed to social stress
Social stress is well known to be involved in the occurrence and exacerbation of mental illness, and also various life-style related diseases such as hyperinsulinemia, hyperglycemia, cardiovascular diseases and cancer. However, there is little information on tissue-specific gene expression in respon...
ORGANISM(S): Mus musculus 
2009-04-19 | E-GEOD-12693 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood leukocytes from CHASRS particpants
Gene expression profiling was carried out on peripheral blood leukocytes from 14 healthy older adults. The primary research question is whether gene expression differs in individuals experiencing chronically high levels of social isolation (by UCLA Loneliness Scale) vs chronically low levels of soc...
ORGANISM(S): Homo sapiens 
2009-04-23 | E-GEOD-7148 | biostudies-arrayexpress
ProteomicsPrefrontal cortex cytoplasmic proteome and machine learning-based predictors of resilience towards chronic social isolation in rats
Chronic social isolation (CSIS) generates two stress-related phenotypes, resilience and susceptibility. Although brain energy metabolism is important in regulating social behaviors, the molecular mechanisms underlying CSIS resilience remain unclear. To identify protein changes and altered biochemica...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-04-23 | PXD048641 | Pride
Lc-msms Rat Brain Machine learning Dda 
TranscriptomicsGene Expression Changes during Chronic Social Isolation in Drosophila melanogaster
To investigate gene expression changes in Drosophila head tissues during social isolation, we performed RNA-sequencing on fruit fly head samples obtained from male flies that have been group-reared for 7 days (Grp), isolated (single-housed) for 7 days (Iso7) and isolated (single-housed) for only 1 d...
ORGANISM(S): Drosophila melanogaster 
2021-06-15 | GSE137498 | GEO
ProteomicsSocial isolation stress-resilient rats reveal energy metabolic shift in hippocampal nonsynaptic mitochondria
We investigated the relative quantification of proteins in hippocampal cytosolic and nonsynaptic mitochondrial (NSM) fractions of rats exposed to chronic social isolation (CSIS), an animal model of depression, comparing CSIS-resilient with CSIS-sensitive or control rats, via a comparative subproteom...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-25 | PXD016966 | Pride
Resilience Hippocampus Rat Proteome Nonsynaptic mitochondria Lc-ms/ms 
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