Sort   by:  
 Page size 
MetabolomicsMetabolic Reprogramming and Reliance in Human Skin Wound Healing
Impaired skin wound healing is a significant global health issue, especially among the elderly. Wound healing is a well-orchestrated process involving the sequential phases of inflammation, proliferation, and tissue remodeling. Although wound healing is a highly dynamic and energy-requiring process,...
2024-07-02 | MTBLS3315 | MetaboLights
MetabolomicsFree fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we ana...

2026-01-06 | MTBLS13603 | MetaboLights
ProteomicsCold Atmospheric Plasma Jet Activated Medium Promotes Wound Healing through CK2-mediated ERK and AKT signaling pathways
In this study, we aimed to explore the molecular mechanisms of wound healing affected by CAPJ using the parallel MS-based proteome and phosphoproteome. The keratinocyte, HaCaT, was used as cell mode to treat CAPJ indirectly by employing plasma activated medium (PAM) which was culture medium explored...
ORGANISM(S): Homo Sapiens (human) 
2025-02-22 | PXD050065 | JPOST Repository
TranscriptomicsmiRNA regulation in diabetes associated impaired wound healing
Circulating miRNAs constitute a novel class of disease biomarkers, which are altered in diabetes but the effect of diabetes associated inflammation as seen in chronic wounds is unknown. We here compared the miRNA pattern in diabetic patients in presence or absence of chronic wound with PAD. The clin...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-49885 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wounds from ovariectomized MIF null mice and controls to investigate the role of MIF during wound healing using BALB/C MIF null mice
The aim of this experiment was to investigate the role of MIF during wound healing using BALB/C MIF null mice and in the context of reduced estrogen-associated impaired healing using ovariectomized mice (a mouse model of age-associated delayed healing). Ageing is associated with delayed cutaneous wo...
ORGANISM(S): Mus musculus 
2005-11-05 | E-MEXP-209 | biostudies-arrayexpress
TranscriptomicsMicrosensor and transcriptome signatures of oxygen depletion in biofilms associated with chronic wounds [biofilm inoculum]
Biofilms have been implicated in delayed wound healing, although the mechanisms by which biofilms impair wound healing are poorly understood. Many species of bacteria produce exotoxins and exoenzymes that may inhibit healing. In addition, oxygen consumption by biofilms, as well as responding leukocy...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2015-11-24 | E-GEOD-75359 | biostudies-arrayexpress
MetabolomicsHUMSCs repair CCl4-induced chronic liver injury in rats via metabolic regulation

To explore the effect of human umbilical cord mesenchymal stem cells (HUMSCs) on repairing CCl4-induced chronic liver injury in rats by intravenous injection and analyze the promising metabolites.

2026-02-03 | MTBLS13826 | MetaboLights
ProteomicsQuantitative proteomic characterization of Foreign Body Response towards silicone breast implants identifies chronological disease-relevant biomarker dynamics
The aim of this work was to enlighten the disease progression from implant insertion and immediate tissue damage response reflected in (a) the acute wound proteome, and (b) the adsorption of chronic inflammatory wound proteins at implant surfaces. An intra-individual relative quantitation TMT-liquid...
ORGANISM(S): Homo sapiens (Human) 
2023-02-24 | PXD039840 | Pride
Smi (silicone mammary implants)  fbr (foreign body response)  wound healing  wound infection  capsular fibrosis  implant encapsulation  early-stage fibrosis  surface adsorption  immunomics  biomarkers 
TranscriptomicsTranscription profiling by array of wound samples from rats treated with the 5alpha-reductase inhibitor MK-434
The present study aimed to delineate the central mechanisms by which androgens delay wound repair. Blocking the conversion of testosterone to 5alpha-dihydrotestosterone (DHT) by 5alpha-reductase limits its ability to impair skin wound healing, suggesting that DHT is a more potent inhibitor of repair...
ORGANISM(S): Rattus norvegicus 
2009-02-20 | E-MEXP-1232 | biostudies-arrayexpress
TranscriptomicsHOXA3 expression in wound tissue
To investigate how HOXA3 expression in wound tissue alters gene expression to control selective recruitment of bone marrow-derived cell populations, we utilized murine whole genome expression arrays (MEEBO arrays) to identify differentially expressed genes in cutaneous wounds from db/db (diabetic) m...
ORGANISM(S): Mus musculus 
2009-10-12 | E-GEOD-13324 | biostudies-arrayexpress
Sort   by:  
 Page size