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GenomicsTranscription factor Achaete-Scute homologue 2 initiates T follicular helper cell development [ChIP-Seq]
In immune responses, activated T cells migrate to B cell follicles and develop to T follicular helper (Tfh) cells, a new subset of CD4+ T cells specialized in providing help to B lymphocytes in the induction of germinal centers 1-3. Although Bcl6 has been shown to be essential in Tfh cell function, ...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-52839 | biostudies-arrayexpress
ProteomicsBlocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB pathway
Clinical trials have demonstrated that CXCR4 antagonists enhance the efficacy of immunotherapy in cancers by reducing regulatory T (Treg) cells, elucidating how certain mechanisms of CXCR4 in affecting Treg cells are essential for developing immunotherapeutic strategies.
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058262 |
ProteomicsProteomic response of rat hippocampus under chronic unpredicted mild stress reveals insights into susceptibility and insensitivity to depression
We used a chronic unpredicted mild stress (CUMS) protocol to separate depression-susceptible and stress-insensitive rat subgroups. Differential proteomes in the hippocampus were analyzed based on isobaric tags for relative and absolute quantitation (iTRAQ) labeling combined with mass spectrometry.
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-17 | PXD025773 | Pride
Hippocampus Depression Chronic unpredicted mild stress Proteome 
UnknownGlycolysis-related biomarker TCIRG1 participates in regulation of renal cell carcinoma progression and tumor immune microenvironment by affecting aerobic glycolysis and AKT/mTOR signaling pathway.
Not available
S-EPMC10468907 | biostudies-literature
UnknownChimeric antigen receptor T cells targeting FcRH5 provide robust tumour-specific responses in murine xenograft models of multiple myeloma.
Not available
S-EPMC10282100 | biostudies-literature
UnknownDiscovery and characterization of novel jeilongviruses in wild rodents from Hubei, China.
Not available
S-EPMC11201313 | biostudies-literature
UnknownKLRG1 re-defines a leukemic clone of CD8 effector T cells sensitive to PI3K inhibitor in T cell large granular lymphocytic leukemia.
Not available
S-EPMC12047471 | biostudies-literature
UnknownTreatment of metastatic non-small cell lung cancer with NY-ESO-1 specific TCR engineered-T cells in a phase I clinical trial: A case report.
Not available
S-EPMC6256329 | biostudies-literature
UnknownRegulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.
Not available
S-EPMC8444427 | biostudies-literature
ProteomicsMultidimensional proteomic landscape of intercellular signaling in pancreatic cancer
We developed a multidimensional proteomic strategy to profile the glycosylated secreted and plasma membrane (S-PM) proteome of 100 human pancreatic tissue samples to an unprecedented depth, define cell-type origins of these S-PM proteins through spatial proteomics, and identify potential paracrine c...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-08-19 | PXD048644 | Pride
Human Spatial proteomics Phosphoproteomics Pancreatic cancer Shedding Prm Glycoproteomics Mouse Dda Lc-ms/ms 
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