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ProteomicsDomain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating its tumor suppressive functions, and by conferring aberrant pro-carcinogenic activities. We report here that mis-sense mutants in the p53 DNA-binding domain (DBD) and the transactivation domain (TAD) unexpectedly activate...
ORGANISM(S): Homo Sapiens (human) 
2023-02-17 | PXD031725 | JPOST Repository
ProteomicsA transient protein folding response targets aggregation in the early phase of TDP-43-mediated disease
Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we generated a longitudinal quantitative proteomic map of the cortex from the cytoplasmic TDP-43 rNLS8 mouse model of ALS and FTLD ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-31 | PXD042382 | Pride
Ftld Longitudinal Als Cortex Mouse Proteinopathy Motor neuron disease Mnd Tdp-43 Lc-ms/ms Tandem mass tagging Amyotrophic lateral sclerosis Frontotemporal dementia Ftd Frontotemporal lobar degeneration 
TranscriptomicsRNA-Seq of oral squamous cell carcinomas and matched normal tissues
RNA-Seq was applied to oral squamous cell carcinomas and matched normal oral tissue to measure gene expression patterns and identify examples of allelic imbalance. Oral squamous cell carcinomas (OSCC) and matched normal tissue from 3 patients.
ORGANISM(S): Homo sapiens 
2010-02-25 | E-GEOD-20116 | biostudies-arrayexpress
UnknownMapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes.
Not available
S-EPMC11364864 | biostudies-literature
TranscriptomicsGSK8814: a chemical probe fort he ATAD2 bromodomain
Differential gene expression analysis of LNCaP cells treated with GSK8814 and GSK8815 Total RNA obtained from cells treated with GSK8814 and GSK8815 for 24 hours
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-78868 | biostudies-arrayexpress
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