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ProteomicsMCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially i...
ORGANISM(S): Homo sapiens (Human) 
2020-06-15 | PXD019156 | Pride
C17orf53 Mcm9 Mcm8 Mcm8ip Cisplatin Rpa Homologous recombination 
ProteomicsSMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
Although genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor rejection, cancer cells often evade these responses by overexpressing immune checkpoint regulators, such as PD-L1. Here, we identify the SNF2-family DNA translocase SMARCAL1 as a factor that favors t...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD046384 | Pride
Smarcal1 Mda-mb-436 cells Bioid 
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