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TranscriptomicsHyperosmotic-induced changes in lymphoid cell gene expression
We have taken S49 Neo cells (an immature murine T-cell line) through repeated exposures of 500 mOsm Mannitol for 4 hours, killing over 90% of the cells, and then allowed them to recover. After 25 rounds of Mannitol exposure, we observed that these cells now have the ability to volume regulate upon ...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-62531 | biostudies-arrayexpress
TranscriptomicsHes1 and Liver Glucocorticoid Signaling
To investigate the role of HES1 during glucocorticoid signaling in the liver, we employed whole-genome microarray expressions in liver mRNA extracted from control and Hes1-liver knockout male mice (HESKOL) that had been adrenalectomized to remove endogenous glucocorticoids. RNA isolated from the liv...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-52106 | biostudies-arrayexpress
TranscriptomicsRole of Serine 134 phosphorylation of the glucocorticoid receptor (GR) in glucocorticoid signaling
In response to environmental stressors and a variety of inflammatory cytokines, p38 MAPKs become directly activated. Here we report the human glucocorticoid receptor (GR) Serine 134 as a novel target for p38 MAPK. Unlike most other phosphorylation events that occur on the GR, phosphorylation of Ser1...
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-28912 | biostudies-arrayexpress
TranscriptomicsSexual Dimorphic Regulation of Liver Gene Expression by Glucocorticoids
Males and females exhibit differences in the incidence of many major diseases including auto-immune diseases, hepatocellular carcinoma, diabetes, and osteoporosis, which all have important inflammatory components in their etiology. Glucocorticoids are the primary physiological anti-inflammatory horm...
ORGANISM(S): Rattus norvegicus 
2010-10-01 | E-GEOD-13461 | biostudies-arrayexpress
TranscriptomicsHes1 and Glucocorticoid Signaling in Bone Sarcoma Cells
To investigate the role of HES1 during glucocorticoid signaling in bone sarcoma cells (U2OS-GR cells) , we employed whole-genome microarray expressions in mRNA extracted from control U2OS-GR and Hes1-overexpressed U2OS-GR cells. RNA isolated from control U2OS-GR and Hes1-overexpressed U2OS-GR cells...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-52727 | biostudies-arrayexpress
TranscriptomicsGlucocorticoids in maintaining cardiac homeostasis in C57bl/6 (wild-type) mice
To further understand the genomic effects of glucocorticoids in the heart we performed microarray studies on hearts collected from long-term ADX-mice. Our objective is to find cardiac specific genes regulated by glucocorticoids. C57bl/6 (wild-type) mice were adrenalectomized. Hearts were collected f...
ORGANISM(S): Mus musculus 
2016-06-09 | E-GEOD-83202 | biostudies-arrayexpress
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