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ProteomicsTop-down Nanoparticle-corona by cIEF-MS/MS
In the rapidly evolving field of nanomedicine, understanding the interactions between nanoparticles and biological systems is crucial. A pivotal aspect of these interactions is the formation of a protein corona when nanoparticles are exposed to biological fluids, which significantly influences their...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD052764 | Pride
Proteoforms Top-down proteomics Cief-ms/ms Nanoparticles Post-translational modifications Nanomedicine Protein corona 
ProteomicsAn improved capillary isoelectric focusing-mass spectrometry method for characterization of monoclonal antibody charge variants
Here, we improved the stability and enhanced separation resolution of automated cIEF-MS by bettering the quality of capillary neutral coating, reducing catholyte pH to 10 for cIEF-MS for the first time, and systematically optimizing the cIEF separation conditions for characterization of monoclonal a...
ORGANISM(S): Homo sapiens (Human) 
2026-08-19 | PXD082799 | Pride
Monoclonal antibody charge variants Cief-ms 
UnknownCapillary Isoelectric Focusing of Proteins and Peptides Using an In-Line cIEF-ESI Interface with Improved MS Characteristics.
Not available
S-EPMC11740900 | biostudies-literature
UnknownEvaluation of a cIEF Fractionation Workflow for Offline MS Analysis of Charge Variants of the Monoclonal Antibody Matuzumab.
Not available
S-EPMC11865688 | biostudies-literature
ProteomicsAutomated capillary isoelectric focusing-tandem mass spectrometry for top-down proteomics
Mass spectrometry (MS)-based top-down proteomics (TDP) delineates proteoforms in cells and requires high-resolution proteoform separation. Herein, for the first time, we employed an automated capillary isoelectric focusing-tandem MS (cIEF-MS/MS) system for large-scale TDP of complex proteomes. Singl...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Escherichia coli 
2020-12-08 | PXD020342 | Pride
Endogenous hormone proteoforms/gel-free 2d-page/multi-level proteomics/ sexual dimorphism/zebrafish brain 
UnknownAutomated Capillary Isoelectric Focusing-Tandem Mass Spectrometry for Qualitative and Quantitative Top-Down Proteomics.
Not available
S-EPMC8564864 | biostudies-literature
UnknownOn-line amino acid-based capillary isoelectric focusing-ESI-MS/MS for protein digests analysis.
Not available
S-EPMC3474973 | biostudies-literature
UnknownInvestigating native capillary zone electrophoresis-mass spectrometry on a high-end quadrupole-time-of-flight mass spectrometer for the characterization of monoclonal antibodies.
Not available
S-EPMC7906288 | biostudies-literature
UnknownCapillary isoelectric focusing-tandem mass spectrometry and reversed-phase liquid chromatography-tandem mass spectrometry for quantitative proteomic analysis of differentiating PC12 cells by eight-plex isobaric tags for relative and absolute quantification.
Not available
S-EPMC3759156 | biostudies-literature
UnknownTop-Down Proteomic Profiling of Protein Corona by High-Throughput Capillary Isoelectric Focusing-Mass Spectrometry.
Not available
S-EPMC11964827 | biostudies-literature
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