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MetabolomicsExamining the effects of cigarette smoke on mouse lens through a multi OMIC approach
Here, we report a multi OMIC (transcriptome, proteome, and metabolome) approach to investigate molecular changes in lens fiber cells (FC) of mice exposed to cigarette smoke (CS). Pregnant mice were placed in a whole-body smoke chamber and a few days later pups were born, which were exposed to CS for...
2024-03-24 | MTBLS207 | MetaboLights
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
MetabolomicsMulti-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
Cigarette smoke (CS) causes adverse health effects and leads to the development of respiratory disease (chronic obstructive pulmonary disease), cardiovascular disease, and cancer. To reduce the risk of smokers developing smoking-related diseases, Philip Morris International is developing modified ri...
2020-04-25 | MTBLS158 | MetaboLights
TranscriptomicsHuman airway epithelial responses to rhinovirus infection and cigarette smoke extract alone and in combination
This study was performed to test the hypothesis that cigarette smoke extract would alter the responses of primary cultures of human bronchial epithelial cells to infection with purified human rhinovirus 16. The data show marked alterations in rhinovirus-induced expression profiles of a number of gen...
ORGANISM(S): Homo sapiens 
2011-03-15 | E-GEOD-27973 | biostudies-arrayexpress
TranscriptomicsMitochondrial mutations in cigarette smoke extract-chronically treated human oral OKF6 cells
The objective of this study was to analyze the mitochondrial mutations induced by chronic cigarette smoke extract treatment in human oral immortal OKF6 cells. The objective of this study was to analyze the mitochondrial mutations induced by chronic cigarette smoke extract treatment in human oral imm...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-24414 | biostudies-arrayexpress
ProteomicsSmooth Muscle Cell Phenotypic Switch Induced by Cigarette Smoke Condensate
Cigarette smoke is a risk factor for inflammatory diseases, such as atherosclerosis. Tobacco smoke interacts with inflammatory cytokines to produce endothelial dysfunction and induces pro-inflammatory and pro-atherosclerotic effects in vascular tissue. Smooth muscle cells (SMCs) are present in the m...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD041174 | Pride
Atherosclerosis  cigarette smoke  electronic cigarette  phenotypic switch  smooth muscle cells 
ProteomicsProteomic analysis of vocal fold fibroblasts exposed to cigarette smoke extract
Reinke’s edema is a cigarette associated, benign, mostly bilateral lesion of the vocal folds leading to dysphonia and dyspnea. Until today information about pathophysiology is only scarce, treatment is only surgical. To explore the pathophysiology of Reinke’s edema, we exposed near primary human voc...
ORGANISM(S): Homo sapiens (Human) 
2019-08-06 | PXD010640 | Pride
Cigarette smoke extract Fibroblasts Proteomics 
TranscriptomicsGene expression data on lungs of wild-type and Rora (Retinoic acid related orphan receptor) mutant mice exposed to room air and smoke
Gene expression data on wild-type and Rora mutant mice exposed to room air and smoke. The results provide a general insight into the relationship of Rora to known DNA damage response pathways and its role in cigarette smoke-induced airspace enlargement. This dataset includes 4 wild-type mice exposed...
ORGANISM(S): Mus musculus 
2012-07-22 | E-GEOD-33512 | biostudies-arrayexpress
ProteomicsNaringenin targets PI3K p85alpha to suppress PI3K/AKT signaling pathway and ameliorate disordered MMP-9 secretion in cigarette smoke extract-induced alveolar macrophages in vitro
Naringenin has demonstrated potential therapeutic effects against cigarette smoke-induced lung injury; however, its underlying mechanisms of regulating matrix metalloproteinase-9 (MMP-9) in alveolar macrophages remain unclear. Methods: The regulatory mechanisms of naringenin in cigarette smoke extra...
ORGANISM(S): Mus Musculus 
PXD063137 |
TranscriptomicsDonor-to-donor variation in gene expression profile of 3D bronchial epithelial cells after cigarette smoke exposure
Three-dimensional (3D) cultured primary cells are used to predict the toxicity of substances towards humans because these 3D cultures closely mimic the physiological architecture of tissues. Nonetheless, it is important to consider primary-cell-specific variability for endpoint selection and appropr...
ORGANISM(S): Homo sapiens 
2022-05-20 | E-MTAB-11316 | biostudies-arrayexpress
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