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MetabolomicsUntargeted UPLC-MS/MS metabolomics of zebrafish gut tissue after chronic ciprofloxacin exposure
This project provides untargeted metabolomics data of zebrafish gut tissue from adult wild-type AB strain zebrafish (Danio rerio) under control conditions and chronic ciprofloxacin (CIP) exposure at 5,000 ng/L for 30 days.
2026-09-09 | MTBLS15610 | MetaboLights
MetabolomicsCiprofloxacin-induced metabolic disruption and stringent response drives persistent small-colony variants in Staphylococcus aureus

Antibiotic treatment failure in Staphylococcus aureus infections is frequently associated with antimicrobial resistance or the emergence of small-colony variants (SCVs), a metabolically quiescent phenotype that complicates infection management. Here, we show that ciprofloxacin induces a stable SC...

2025-11-19 | MTBLS13343 | MetaboLights
TranscriptomicsPAO1-Lon-ciprofloxacin
Microarray experiments were preformed comparing the effect of sub-inhibitory concentrations of ciprofloxacin on five independent cultures of PAO1 and the PAO1 Lon mutant
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2012-03-25 | E-MTAB-1000 | biostudies-arrayexpress
no omics definedTranscription profiling time series of Pseudomonas aeruginosa wild type and lexA mutant response to treatment with ciprofloxacin
Pseudomonas aeruginosa infections can be virtually impossible to eradicate and the evolution of resistance during antibiotic therapy is a significant concern. In this study, we use DNA microarrays to characterize the global transcriptional response of P. aeruginosa to clinical-like doses of the ant...
ORGANISM(S): Pseudomonas aeruginosa 
2007-09-21 | E-GEOD-5443 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ciprofloxacin induction of a susceptibility determinant in Pseudomonas aeruginosa
PAO1 was grown in sub-inhibitory ciprofloxacin (0.1x-, 0.3x-, 1x-MIC) until log phase. Microarrays were done on total RNA isolated from these cultures. Loop design and dye swapping were used.
ORGANISM(S): Pseudomonas aeruginosa 
2013-01-30 | E-FPMI-1 | biostudies-arrayexpress
TranscriptomicsY. pestis exposed to various concentrations of ciprofloxacin for various time points (treated/nontreated analysis in each array).
Cultures of Y. pestis Kimberley53 virulent strain were exposed to different concentrations of ciprofloxacin (including 0.016 µg/ml representing the strains' MIC value) for various time periods. Total RNA samples were extructed and used for cRNA synthesis and labelling (using Cy3-CTP for the treated...
ORGANISM(S): Yersinia pestis 
2016-03-30 | E-GEOD-79687 | biostudies-arrayexpress
TranscriptomicsSalmonella enteritidis ciprofloxacin resistance effect on transcription in LB
comparison of total RNA profiles obtained from ciprofloxacin resistant colonies of two separate Enteritidis isolates with their respective wt parents total RNA of both wt (with reduced cip sensitivity at MIC=0.2 ug/ml) and spontaneous cipR mutants (MIC>32ug/ml) in LB log phase was harvested from Ent...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Enteritidis 
2010-06-25 | E-GEOD-15024 | biostudies-arrayexpress
GenomicsIdentification of genes important for response of Pseudomonas aeruginosa biofilms to ciprofloxacin exposure using TraDIS-Xpress
Pseudomonas aeruginosa is an opportunistic pathogen that can cause severe infections in immunocompromised individuals, such as patients with cystic fibrosis where it commonly forms biofilms. Ciprofloxacin is used extensively to treat P. aeruginosa infections, but its effectiveness can be significant...
ORGANISM(S): Pseudomonas aeruginosa 
2026-06-09 | E-MTAB-16928 | biostudies-arrayexpress
TranscriptomicsS. coelicolor, Control (untreated) Vs Ciprofloxacin treated
Transcriptional profiling of S. coelicolor comparing control untreated cells with ciprofloxacin treated cells. Two-condition experiment, Control Vs CIP treatment. Biological replicates: 3 control, One dye swap replicate. four samples and three biological replicate to study the response of S. coleico...
ORGANISM(S): Streptomyces coelicolor 
2014-01-01 | E-GEOD-49788 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Campylobacter jejuni wild-type 81-176 and its ciprofloxacin-resistant derivative (P3) in the presence and absence of ciprofloxacin
Campylobacter jejuni is one of the most important zoonotic enteric bacterial pathogens able to colonize the gastrointestinal tract of various animals. The number of campylobacteriosis cases has increased worldwide and the particular concern has been the high level of fluoroquinolone resistance obser...
ORGANISM(S): Campylobacter jejuni subsp. jejuni 81-176 
2012-12-31 | E-GEOD-41822 | biostudies-arrayexpress
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