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TranscriptomicsMicroarray expression profile analysis of circular RNAs in human pancreatic ductal adenocarcinoma
To explore the potential involvement of circular RNAs (circRNAs) in pancreatic ductal adenocarcinoma (PDAC) oncogenesis, we conducted circRNA profiling in six pairs of human PDAC and adjacent normal tissue by microarray. Our results showed that clusters of circRNAs were aberrantly expressed in PDAC ...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-69362 | biostudies-arrayexpress
TranscriptomicsCircular RNAs are a large class of animal RNAs with regulatory potency (PAR-CLIP)
Circular RNAs (circRNAs) in animals are an enigmatic class of RNAs with unknown function. To systematically explore circRNAs, we sequenced and computationally analyzed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, with oftentimes tissue/developmental stage ...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-43573 | biostudies-arrayexpress
TranscriptomicsAn improved method for identifying biological circular RNAs
Purpose: We are using the illumina sequencing to compare the false positive and true positive circular RNA findings to confine the method to detect the true circular RNAs Methods: The testis whole transcriptome profiling was generated from 4-week mouse testis using illumina Nextseq, duplicated. The ...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-83992 | biostudies-arrayexpress
TranscriptomicsTissue-specific circular RNA induction during human fetal development
The pervasive expression of circular RNA from protein coding loci is a recently discovered feature of many eukaryotic gene expression programs. Computational methods to discover and quantify circular RNA are essential to the study of the mechanisms of circular RNA biogenesis and potential functiona...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-64283 | biostudies-arrayexpress
TranscriptomicsAnalysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals
Circular RNAs (circRNAs) are a large class of animal RNAs. To investigate possible circRNA functions, it is important to understand circRNA biogenesis. Besides human Alu repeats, sequence features that promote exon circularization are largely unknown. We experimentally identified new circRNAs in C. ...
ORGANISM(S): Caenorhabditis elegans 
2015-01-06 | E-GEOD-63823 | biostudies-arrayexpress
GenomicsRole of SRRM4 in regulating microexons in Circular RNAs
Role of SRRM4 in regulating microexons in Circular RNAs
PRJNA625891 | ENA
TranscriptomicsCircular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types
Most human pre-mRNAs are spliced into linear molecules that retain the exon order defined by the genomic sequence. By deep sequencing of RNA from a variety of normal and malignant human cells, we found RNA transcripts from many human genes in which the exons were arranged in a non-canonical order. ...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-33772 | biostudies-arrayexpress
TranscriptomicsCircular RNAs are a large class of animal RNAs with regulatory potency (RNA-Seq)
Circular RNAs (circRNAs) in animals are an enigmatic class of RNAs with unknown function. To systematically explore circRNAs, we sequenced and computationally analyzed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, with oftentimes tissue/developmental stage ...
ORGANISM(S): Homo sapiens 
2013-02-28 | E-GEOD-43572 | biostudies-arrayexpress
GenomicsRole of SRRM4 in regulating microexons in Circular RNAs in brain tissue
Role of SRRM4 in regulating microexons in Circular RNAs in brain tissue
PRJNA668150 | ENA
ProteomicsCytoplasmic DIS3 degrades circular RNAs independently of the exosome
Circular RNAs (circRNAs) are frequently generated during splicing. Their physiological roles, however, remain largely elusive. Some specific circRNAs function as microRNA (miRNA) or RNA binding protein (RBP) sponges or encode for proteins and are actively translated. Due to the lack of accessible en...
ORGANISM(S): Homo sapiens (Human) 
2025-05-05 | PXD050442 | Pride
Exosome Circular rnas Dis3 Degradation Circrna 
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