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MetabolomicsProtein lactylation of citrate synthase promotes the AKI–CKD transition by activating the NLRP3 inflammasome.

Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, protein lactylation modification has emerged as a novel mechanism for mediating chronic organ damage. We investigated lactylated protein profiles and the role of...

2025-06-17 | MTBLS12606 | MetaboLights
MetabolomicsMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, ...
2021-03-05 | MTBLS2159 | MetaboLights
MetabolomicsF1Fo-ATP synthase subunit determines lethal pathogenic fungi infection
Fungal infections, especially candidiasis and aspergillosis, claim an unacceptably high fatality rate. The energy ATP that is necessary for fungal cell growth and function is synthesized mainly through oxidative phosphorylation, with the key enzyme being F1Fo-ATP synthase. But it remains unknown how...
2021-10-08 | MTBLS3332 | MetaboLights
GenomicsAnaplasma capra strain:citrate synthase (gltA) | isolate:Turkey_goat_135
Anaplasma capra strain:citrate synthase (gltA) | isolate:Turkey_goat_135 Genome sequencing
PRJNA948798 | ENA
MetabolomicsHaplotype-specific expression of a terpene synthase underlies linalool variation in the grapevine cultivar Riesling
Grapevine cultivars vary widely in monoterpenoid content, yet the genetic and regulatory mechanisms underlying this variation remain poorly characterized beyond highly aromatic Muscat types. We profiled free volatiles and monoterpenoid glycosides in a Riesling × Cabernet Sauvignon F1 mapping populat...
2026-06-28 | MTBLS14608 | MetaboLights
ProteomicsProtein Succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity
The cytokines tumor necrosis factor ligand superfamily member 11 (TNFSF11; also known as RANKL) and macrophage colony-stimulating factor 1 receptor (M-CSF) differentiate macrophages into bone-resorbing osteoclasts via a process characterised by changes in metabolic activity that support energy-consu...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD060675 | Pride
Succinylation Post translational modification Steoclast Citrate synthase Rankl 
TranscriptomicsGene expression analysis in 13 patients with mitochondrial ATP synthase deficiency (Agilent)
Defects of mitochondrial functions lead in humans to vast array of usually multisystemic pathologies and several hundreds of diseases resulting from various defects of mitochondria biogenesis and maintenance, defects of respiratory chain complexes (OXPHOS) or defects of individual mitochondrial prot...
ORGANISM(S): Homo sapiens 
2008-08-01 | E-GEOD-10956 | biostudies-arrayexpress
UnknownRe-citrate synthase from Clostridium kluyveri is phylogenetically related to homocitrate synthase and isopropylmalate synthase rather than to Si-citrate synthase.
Not available
S-EPMC1913417 | biostudies-literature
GenomicsRNA-seq analyses of citrate synthase (CS) knocked down cells
RNA-seq analyses of citrate synthase (CS) knocked down cells
PRJNA1312461 | ENA
UnknownThe Novel Role of Mitochondrial Citrate Synthase and Citrate in the Pathophysiology of Alzheimer's Disease.
Not available
S-EPMC10473122 | biostudies-literature
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