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MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
MetabolomicsThe metabolomic resetting effect of FG4592 in AKI to CKD transition (Part 1)
Not available
ORGANISM(S): Mus musculus 
ST001855 | MetabolomicsWorkbench
MetabolomicsMetabolomic and lipidomic profiles of CKD in obese patients in serum and urine (part 1 of 3)
Not available
ORGANISM(S): Homo sapiens 
ST001824 | MetabolomicsWorkbench
UnknownB. longum CKD1 enhances the efficacy of anti-diabetic medicines through upregulation of IL- 22 response in type 2 diabetic mice.
Not available
S-EPMC10896159 | biostudies-literature
ProteomicsInvestigation of the human-gut-kidney axis by fecal proteomics, highlights molecular mechanisms affected in the later stages of CKD
The interplay of gut microbiota with the kidney system, characteristic to reduced kidney function and increased concentrations of urea in gut; in turn increases bacterial urease activity and generation of uremic toxins. Knowledge on these underlying bidirectional molecular mechanisms is nevertheless...
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD048778 | Pride
Butyrate Ckd Inflammation Gut Bioinformatics Fecal Proteomics Lc-ms/ms 
UnknownCombination of rs-fMRI, QSM, and ASL Reveals the Cerebral Neurovascular Coupling Dysfunction Is Associated With Cognitive Decline in Patients With Chronic Kidney Disease.
Not available
S-EPMC11621384 | biostudies-literature
UnknownInvestigation of the human-gut-kidney axis by fecal proteomics, highlights molecular mechanisms affected in CKD.
Not available
S-EPMC11226915 | biostudies-literature
UnknownAssociation of chronic kidney disease with acute clinical outcomes and hospitalization costs of cancer resection.
Not available
S-EPMC11760676 | biostudies-literature
UnknownEffect of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease by CKD Stage: Results from the TEMPO 3:4 Trial.
Not available
S-EPMC4858477 | biostudies-literature
UnknownClinical global assessment of nutritional status as predictor of mortality in chronic kidney disease patients.
Not available
S-EPMC5718431 | biostudies-literature
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