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ProteomicsTarget search for self-reactive antibodies in human renal allograft rejection
Self-reactive antibodies cloned from B cells infiltrating in a human renal allograft were subjected to IP-mass spectrometry using nuclear lysates of HEp-2 cells.
ORGANISM(S): Homo sapiens (Human) 
2021-04-27 | PXD022989 | Pride
Keywords: renal allograft rejection Transcription Q-exactive Inflammation Scrna-seq Human Human Innate b cells Autoantibodies Lfq Tolerance 
UnknownDeveloping vaccines against epidemic-prone emerging infectious diseases.
Not available
S-EPMC6925075 | biostudies-literature
GenomicsHistone Reader BRWD1 Targets and Restricts Recombination to the Igk Locus
B lymphopoiesis requires that immunoglobulin genes be accessible to RAG1-RAG2 recombinase. However, the RAG proteins bind widely to open chromatin, which suggests that additional mechanisms must restrict RAG-mediated DNA cleavage. Here we show that developmental downregulation of interleukin 7 (IL-7...
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-63302 | biostudies-arrayexpress
TranscriptomicsYeast spore germination: time course
The process of Saccharomyces cerevisiae spore germination includes breakage of dormancy, morphological changes and resumption of vegetative growth. We have determined the global transcriptional response during the first two hours of spore germination in response to rich growth medium and glucose alo...
ORGANISM(S): Saccharomyces cerevisiae 
2012-12-18 | E-GEOD-29960 | biostudies-arrayexpress
UnknownThe GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.
Not available
S-EPMC9150115 | biostudies-literature
TranscriptomicsExpression data from vehicle or PD-0332991 treated human T-ALL lines
Cyclin D3 is critical hematopoiesis and loss of cyclin D3 leads to resistance to transformation of bone marrow progenitors by Notch1-IC. We used a small molecule targeting cyclin D3:CDK4/6 activity to study whether its inhibition is an effective therapeutic strategy. We analyzed T-ALL lines in vitro...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-40635 | biostudies-arrayexpress
UnknownPsychometric Properties of a Delirium Severity Score for Older Adults and Association With Hospital and Posthospital Outcomes.
Not available
S-EPMC8972033 | biostudies-literature
GenomicsRAG Represents a Widespread Threat to the Lymphocyte Genome - (ChIP-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report the surprising finding that RAG1 bind...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-69475 | biostudies-arrayexpress
GenomicsRAG Represents a Widespread Threat to the Lymphocyte Genome - (Mnase-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report the surprising finding that RAG1 bind...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-69474 | biostudies-arrayexpress
UnknownThe benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial.
Not available
S-EPMC3386495 | biostudies-literature
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