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TranscriptomicsA library of yeast transcription factor motifs
The sequence specificity of DNA-binding proteins is the primary mechanism by which the cell recognizes genomic features. Here, we describe systematic determination of yeast transcription factor DNA-binding specificities. We obtained binding specificities for 112 DNA-binding proteins representing 19 ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-26 | E-GEOD-12349 | biostudies-arrayexpress
TranscriptomicsImpact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-l-galactose phosphorylase
The l-galactose (Smirnoff-Wheeler) pathway represents the major route to l-ascorbic acid (vitamin C) biosynthesis in plants. Arabidopsis thaliana VTC2 and its paralogue VTC5 function as GDP-l-galactose phosphorylases converting GDP-l-galactose to l-galactose-1-P, thus catalyzing the first committed ...
ORGANISM(S): Chlamydomonas reinhardtii 
2012-05-02 | E-GEOD-34826 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the maturing erythroblast
Understanding the pattern of gene expression and identifying the specific genes expressed during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here we have isolated four distinct populations of erythroblasts at successive erythropoietin-dependent stages of erythropoie...
ORGANISM(S): Homo sapiens 
2011-03-02 | E-GEOD-22552 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of genetically matched normal adjacent tissue, primary tumor and metastatic lymph-node to identify cancer and metastasis genes
Profiling of genetically matched normal adjacent tissue, primary tumor and metastatic lymph-node to identify cancer and metastasis genes.
ORGANISM(S): Homo sapiens 
2006-11-21 | E-MEXP-44 | biostudies-arrayexpress
GenomicsA crucial role of the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification [ChIP-Seq]
Mammalian development is regulated by the interplay of tissue-specific and ubiquitously expressed transcription factors, such as Sp1. Sp1 knock-out mice die in utero with multiple phenotypic aberrations, but the underlying molecular mechanism of this differentiation failure has been elusive. Here we...
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-52496 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of muscle gene expression in response to an intense cycling exercise. Effect of two protein-leucine enriched diets
Protein-leucine supplement ingestion following strenuous endurance exercise accentuates skeletal-muscle protein synthesis and adaptive molecular responses, but the underlying transcriptome is uncharacterized. In a randomized single-blind triple-crossover design, 12 trained men completed 100 min of h...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-44818 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human prostate cancer cell line with IRF7 knock-down treated with radiation against wild-type control
Abstract/Project overview Tumour recurrence can be influenced by the mutational status of a tumour but also how the tumour responds to therapy. Whilst activation of Type 1 interferon signalling is a hallmark of how cells respond to viral infection, in cancer cells, multiple stresses are known to a...
ORGANISM(S): Homo sapiens 
2023-07-01 | E-MTAB-9286 | biostudies-arrayexpress
UnknownDe novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Not available
S-EPMC7007577 | biostudies-literature
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
UnknownSingle-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.
Not available
S-EPMC6315111 | biostudies-literature
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