Clarke Paul A PA

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Unknown (68)
Transcriptomics (10)
Proteomics (2)
Metabolomics (1)

Organisms

Homo sapiens (9)
Schizophyllum commune H4-8 (2)
Mycobacterium tuberculosis SP7 (2)
Oryza sativa Japonica Group (2)
Crotalus durissus terrificus (2)
Eriocheir sinensis (2)
Candidatus Endoriftia persephonae (2)
Mycobacterium tuberculosis SP10 (2)
Mycobacterium tuberculosis SP13 (2)
Mycobacterium tuberculosis SP22 (2)
Enterobacter ludwigii (2)
Chlamydomonas reinhardtii (2)
Lama (2)
Pyricularia oryzae P131 (2)
Enterococcus mundtii CRL35 (2)
Pongo pygmaeus (2)
Oncorhynchus tshawytscha (2)
Pseudomonas canadensis (2)
Strongylocentrotus purpuratus (2)
Influenza A virus (A/California/04/2009(H1N1)) (2)
Salmonella enterica subsp. enterica serovar Typhimurium (2)
Homo (2)
Bradyrhizobium diazoefficiens (2)
Streptococcus pyogenes STAB901 (2)
Pseudomonas aeruginosa PAO1H2O (2)
Megoura viciae (2)
Human alphaherpesvirus 1 strain 17 (2)
Quercus petraea (2)
Canis lupus (2)
Mus musculus (1)

Repository

biostudies-arrayexpress (10)
pride (2)
MetaboLights (1)

Tissue

Permanent cell line cell (1)
Colon (1)
Lung (1)
Epithelial cell (1)

Disease

Non-small cell lung carcinoma (1)
Colon cancer (1)

Technology Type

Mass Spectrometry (2)
Mass spectrometry (1)
Bottom-up proteomics (1)
Data-dependent acquisition (1)
Data-independent acquisition (1)
SWATH MS (1)

Instrument Platform

SYNAPT HDMS (Waters) (1)

Publication Date

2013 (6)
2015 (3)
2025 (2)
2011 (1)
2017 (1)

CHEBI ID

CHEBI:55334 (1)
CHEBI:136935 (1)
CHEBI:136948 (1)
CHEBI:27842 (1)
CHEBI:136946 (1)
CHEBI:136950 (1)
CHEBI:136954 (1)
CHEBI:136951 (1)
CHEBI:136926 (1)
CHEBI:136953 (1)
CHEBI:136955 (1)
CHEBI:136930 (1)
CHEBI:136922 (1)
CHEBI:47791 (1)
CHEBI:50703 (1)
CHEBI:136945 (1)
CHEBI:136942 (1)
CHEBI:136952 (1)
CHEBI:136944 (1)
CHEBI:136939 (1)
CHEBI:28311 (1)
CHEBI:80987 (1)
CHEBI:79324 (1)
CHEBI:80965 (1)
CHEBI:136949 (1)
CHEBI:65019 (1)
CHEBI:1865 (1)
CHEBI:27993 (1)
CHEBI:31969 (1)
CHEBI:80985 (1)

Metabolite Name

Pelargonidin 3-O-rutinoside-5-O-beta-D-glucoside (anthocyanin) (1)
1,2-bis-O-Sinapoyl-beta-D-glucoside (1)
Delphinidin 3-O-(6''-O-malonyl)-β-glucoside (anthocyanin) (1)
Quercetin 3-β-D-glucoside (flavonoid) (1)
Coumaric acid-β-D-glucoside (1)
2,5-Dihydroxybenzoate 2-O-β-D-glucoside (1)
Cinnamoyl beta-D-glucoside (1)
8-(Methylthio)octylisothiocyanate (1)
4-Methoxy-3-indolylmethylamine (1)
Gluconasturtiin (2-phenethyl glucosinolate) (1)
Glucotropaeolin (benzyl glucosinolate) (1)
Glucohirsutin (methylsulfinyloctyl glucosinolate) (1)
Glucoibarin (methylsulfinylheptyl glucosinolate) (1)
Glucohesperin (methylsulfinylhexyl glucosinolate) (1)
Glucoalyssin (methylsulfinylpentyl glucosinolate) (1)
Glucolesquerellin (6-methylthiohexyl glucosinolate) (1)
Glucoraphanin (methylsulfinylbutyl glucosinolate) (1)
Glucoberteroin (methylthiopentyl glucosinolate) (1)
Progoitrin (2-hydroxy-3-butenyl glucosinolate) (1)
Sinigrin (propenyl glucosinolate) (1)
Gluconapin (butenyl glucosinolate) (1)
9-Methylthiononylhydroximoyl-L-cysteine (1)
2-Oxo-9-methylthiononanoate (1)
2-Oxo-6-methylthiohexanoate (1)
Sulfoglucobrassicin (N-sulfoindol-3-yl)-methyl glucosinolate) (1)
Glucobrassicin (indol-3-ylmethyl glucosinolate, I3G) (1)
7-Methylthioheptyl-desulfoglucosinolate (1)
Desulfoglucobrassicin (indolylmethyl-desulfoglucosinolate) (1)
Desulfoglucoberteroin (5-methylthiopentyl-desulfoglucosinolate) (1)
Desulfogluconasturtiin (2-phenylethyl-desulfoglucosinolate) (1)

Study type

Transcription profiling by array (10)

Release Date

2022 (14)
2023 (12)
2021 (9)
2015 (8)
2013 (6)
2024 (6)
2025 (4)
2020 (4)
2016 (4)
2014 (3)
2019 (2)
2017 (2)
2011 (1)
2018 (1)
2012 (1)
2010 (1)

Lab affiliation

Centre for Cancer Drug Discovery Institute of Cancer Research London (1)
Institute of Cancer Research (1)

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Confirmation of cdk8/19 inhibitor selectivity and activity in colorectal cancer

The Mediator complex is an evolutionarily conserved regulator of gene expression, influencing chromatin structure and RNA polymerase II-mediated transcription. Its activity is modulated by a protein kinase module, which includes cyclin-dependent kinases 8 and 19, that phosphorylate RNA polymerase II...

ORGANISM(S): Homo sapiens (Human)

2025-07-28 | PXD061476 | Pride

Proteome profiling followng targeting eIF4E

Here we have compared the impact of loss the protein synthesis initiation factor eIF4e in non samll cell lung cancer cells. Expression of eIF4E was targeted by an eIF4E siRNA or by expressiojn of eIF4E-dTAG construct allowing degradation of eIF4e-dTAG with the heterobifunctional dTAGv-1 small molecu...

ORGANISM(S): Homo sapiens (Human)

2025-05-07 | PXD057122 | Pride

Human Cancer Lung Dtag Protein synthesis Eif4e Sirna

The Lipopolysaccharide-Induced Metabolome Signature in Arabidopsis thaliana Reveals Dynamic Reprogramming of Phytoalexin and Phytoanticipin Pathways

Lipopolysaccharides (LPSs), as MAMP molecules, trigger the activation of signal transduction pathways involved in defence. Currently, plant metabolomics is providing new dimensions into understanding the intracellular adaptive responses to external stimuli. The effect of LPS on the metabolomes of Ar...

2017-05-03 | MTBLS272 | MetaboLights

An Invasive Gene Expression Signature in Pancreas Cancer

Gene expression profiling has demonstrated clinical utility as a predictive tool in clinical oncology. We have identified genes associated with invasion of pancreatic cancer, and with potential for identifying early recurrence. We used Affymetrix Human U133 Plus 2.0 microarrays to identify specific ...

ORGANISM(S): Homo sapiens

2011-01-01 | E-GEOD-22973 | biostudies-arrayexpress

Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]

There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...

ORGANISM(S): Mus musculus

2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress

Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [Colo205]

ORGANISM(S): Homo sapiens

2015-10-26 | E-GEOD-67845 | biostudies-arrayexpress

Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [LS-174-T]

ORGANISM(S): Homo sapiens

2015-10-26 | E-GEOD-67846 | biostudies-arrayexpress

A Quality Improvement Project to Minimize COVID-19 Infections in Patients Receiving Haemodialysis and the Role of Routine Surveillance Using Nose and Throat Swabs for SARS-CoV-2 rRT-PCR and Serum Antibody Testing.

Not available

S-EPMC8805076 | biostudies-literature

The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial.