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GenomicsPTIP promotes chromatin changes critical for immunoglobulin class switch recombination
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here we show that activated B cells deficient in the PTIP component of the MLL3 (mix...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20852 | biostudies-arrayexpress
TranscriptomicsThe DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination
Class-switch recombination (CSR), induced by activation-induced cytidine deaminase, can be divided into two phases: DNA cleavage of the switch (S) regions, and the joining of the cleaved ends of the different S regions. Here, we show that the DSIF complex (Spt4 and Spt5), a transcription elongation ...
ORGANISM(S): Mus musculus 
2013-10-22 | E-GEOD-33206 | biostudies-arrayexpress
GenomicsGenome-wide localization of Smc1, Smc3 and CTCF in mouse B cells.
Immunoglobulin class switch recombination (CSR) is initiated by the transcription-coupled recruitment of activation induced cytidine deaminase (AID) to switch regions and by the subsequent generation and resolution of dsDNA breaks (DSBs). During, CSR the IgH locus undergoes dynamic three-dimensional...
ORGANISM(S): Mus musculus 
2013-10-11 | E-GEOD-43594 | biostudies-arrayexpress
ProteomicsDYRK1A regulates B cell class switch recombination through phosphorylation of MSH6
Effective protection from viral infections depends on the antibody-specific isotype. Here, we found that the protein kinase, DYRK1A, is essential for B cell-mediated protection from viral infection and vaccination through regulation of class switch recombination (CSR). Dyrk1a-deficient B cells were ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-16 | PXD034156 | Pride
Antibody Clonal selection B cell Class-switch recombination Humoral immunity 
TranscriptomicsAcetylated Histone Reader Brd4 functions as Repair Adaptor in Immunoglobulin Class Switch Recombination
Class Switch Recombination (CSR) is a B cell specific genomic alteration induced by activation induced cytidine deaminase (AID)-dependent DNA break, followed by repair and recombination at the immunoglobulin heavy-chain locus. The involvement of several chromatin-associated factors in promoting AID-...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-52239 | biostudies-arrayexpress
GenomicsSwitch tandem repeats influence the choice of the alternative end-joining pathway in class switch recombination
Switch tandem repeats influence the choice of the alternative end-joining pathway in class switch recombination
PRJNA729240 | ENA
GenomicsNOP16 regulates the B cell class switch recombination into IgA
NOP16 regulates the B cell class switch recombination into IgA
PRJNA1234127 | ENA
GenomicsLsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination
Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination
PRJNA632014 | ENA
TranscriptomicsOrientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional orientation as adjacent Cμ constant region exons. In mice, six additional sets of c...
ORGANISM(S): Mus musculus 
2015-08-26 | E-GEOD-71005 | biostudies-arrayexpress
GenomicsChromatin-intrinsic mechanisms determine orientation-specific class switch recombination [ChIP-Seq]
Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination [ChIP-Seq]
PRJNA1274249 | ENA
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