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ProteomicsBiomolecular condensation orchestrates clathrin-mediated endocytosis in plants
Clathrin-mediated endocytosis is an essential cellular internalisation pathway involving the dynamic assembly of clathrin and accessory proteins to form membrane-bound vesicles. The evolutionarily ancient TSET/TPLATE complex (TPC) plays an essential, but not well-defined role in endocytosis in plant...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-12-07 | PXD045068 | Pride
Ap-ms Arabidopsis Clathrin-mediated endocytosis Tplate complex Ateh1 
ProteomicsUptake of oomycete RXLR effectors into host cells by clathrin-mediated endocytosis
Filamentous (oomycete and fungal) plant pathogens can deliver cytoplasmic effector proteins into host cells to facilitate disease. How RXLR effectors from the potato late blight pathogen Phytophthora infestans enter host cells is unknown. One possible route involves clathrin-mediated endocytosis (CM...
ORGANISM(S): Phytophthora infestans T30-4 Nicotiana benthamiana 
2023-07-20 | PXD040285 | Pride
Oomycete  rxlr effectors  clathrin mediated endocytosis 
ProteomicsMYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling
As the unique cell type in articular cartilage, chondrocyte senescence is a crucial cellular event contributing to osteoarthritis development. Here we show that clathrin-mediated endocytosis and activation of Notch signaling promotes chondrocyte senescence and osteoarthritis development, which is ne...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-07 | PXD044684 | Pride
Osteoarthritis  chondrocyte senescence  clathrin-mediated endocytosis  myosin light chain 3  notch signaling 
TranscriptomicsA human genome-wide screen for regulators of clathrin-coated vesicle formation
Clathrin-mediated endocytosis is essential for a wide range of cellular functions. We used a multi- step siRNA-based screening strategy to identify novel regulators of the first step of clathrin- mediated endocytosis, formation of clathrin-coated vesicles (CCVs) at the plasma membrane. A primary gen...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-39954 | biostudies-arrayexpress
ProteomicsPhosphorylation of the AP2 μ2 subunit by p70S6 kinase facilitates clathrin-mediated endocytosis.
Clathrin-mediated endocytosis (CME) internalizes cell-surface receptors via clathrin-coated invaginations of the plasma membrane. Both clathrin and endocytic cargo are recruited to these sites by the adaptor protein complex AP2. AP2 cycles between a closed cytoplasmic conformation and an open membra...
ORGANISM(S): Rattus Rattus (black Rat) 
2026-07-31 | PXD080679 | JPOST Repository
UnknownMechanoregulation of clathrin-mediated endocytosis.
Not available
S-EPMC5702056 | biostudies-literature
ProteomicsA novel interaction site determines binding between AP180 and AP2 in clathrin mediated endocytosis
The early phases of clathrin mediated endocytosis are organized through a highly complex interaction network mediated by clathrin associated sorting proteins (CLASPs) that comprise long intrinsically disordered regions (IDRs). AP180 is a CLASP exclusively expressed in neurons and comprising a long I...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2024-07-04 | PXD049300 | Pride
Extended ap180:ap2β2 interaction Xl-ms 
UnknownClathrin-mediated endocytosis cooperates with bulk endocytosis to generate vesicles.
Not available
S-EPMC8841809 | biostudies-literature
ProteomicsVAMP8 function reveals tight linkage between endocytic recycling and endocytosis
Clathrin-mediated endocytosis (CME) is a multistage process that involves the initiation and stabilization of clathrin-coated pits (CCPs) that invaginate and finally detach from the plasma membrane to form clathrin-coated vesicles (CCVs). Given that SNARE proteins are essential for downstream vesicl...
ORGANISM(S): Homo Sapiens 
2026-03-09 | PXD075425 |
TranscriptomicsPeturbation of PICALM Levels Alters Cellular Cholesterol Metabolism
PICALM (Phosphatidyl Inositol Clathrin Assembly Lymphoid Myeloid protein) is a ubiquitously expressed protein that plays a role in clathrin-mediated endocytosis. PICALM also affects the internalization of SNAREs and modulates macroautophagy. Chromosomal translocations that result in the fusion of PI...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-64855 | biostudies-arrayexpress
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