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MetabolomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. Underlying OA pathogenesis is yet to be fully elucidated with no OA specific biomarkers in clinical use. Ex-...
2020-09-30 | MTBLS1495 | MetaboLights
MetabolomicsMetabolomic and Proteomic Stratification of Equine Osteoarthritis

Osteoarthritis (OA) is characterised by loss of articular cartilage, synovial membrane dysfunction and subchondral sclerosis. Few studies have used a global approach to stratify equine synovial fluid (SF) molecular profiles according to OA severity. SF was collected from 58 metacarpophalangeal (M...

2025-10-16 | MTBLS1645 | MetaboLights
MetabolomicsDetermining predictive metabolomic biomarkers of meniscal injury in dogs with cranial cruciate ligament disease

OBJECTIVES: This study used hydrogen nuclear magnetic resonance spectroscopy (1H NMR) for the first-time to examine differences in the metabolomic profile of stifle joint synovial fluid from dogs with cranial cruciate ligament rupture with and without meniscal injuries, in order ...

2025-08-14 | MTBLS6050 | MetaboLights
TranscriptomicsInfluence of Fatty Acid Diets on Gene Expression in Rat Mammary Epithelial Cells
Background: This study examines the impact of dietary fatty acids on regulation of gene expression in the mammary epithelial cells before and during puberty. Methods: The diets primarily consisted of n-9 monounsaturated fatty acids (olive oil), n-6 polyunsaturated fatty acids (safflower), saturated ...
ORGANISM(S): Rattus norvegicus 
2009-04-01 | E-GEOD-14933 | biostudies-arrayexpress
ProteomicsMulti-omics approach to identify age-related changes in mesenchymal stem cells
Mesenchymal stem cells (MSC) are bone-marrow derived cells, capable of multipotent differentiation into connective tissues including bone, tendon and cartilage. They are an attractive source for autologous cell-based treatments for a range of clinical diseases and injuries. MSCs have been demonstra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079981 | MassIVE
UnknownOutcome Measures for Disease-Modifying Trials in Parkinson's Disease: Consensus Paper by the EJS ACT-PD Multi-Arm Multi-Stage Trial Initiative.
Not available
S-EPMC10578294 | biostudies-literature
UnknownOptimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors.
Not available
S-EPMC8366007 | biostudies-literature
UnknownHeterogeneity of proteome dynamics between connective tissue phases of adult tendon.
Not available
S-EPMC7217697 | biostudies-literature
ProteomicsHeterogeneity of proteome dynamics between connective tissue phases of adult tendon
Turnover of matrix proteins is essential to maintain tissue homeostasis, and dysregulation of protein turnover has been implicated in a variety of diseases. However, proteome dynamics in the musculoskeletal system, particularly tendon, remain relatively unexplored. The aim of this study was therefor...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-07-08 | PXD015928 | Pride
Fm Rat tendon Protein turnover Ifm 
ProteomicsStructure-function Relationships in Human Tendons: Interfascicular Matrix Specialisation in the Achilles Tendon C4PR_LIV
Tendon is a highly aligned connective tissue, in which the macro-structure consists of collagen-rich fascicles surrounded by interfascicular matrix (IFM). In a series of recent studies in equine tissue, we have demonstrated specialisation of tendon composition, structure and mechanics to achieve the...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD018212 | Pride
Structure-function Fascicles  interfascicularmatrix  mechanical testing  mass spectrometry  ageing 
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