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Transcriptomics3' sequencing of nuclear and cytoplasmic fractions following treatment with a CLK inhibitor
CLK kinases phosphorylate the SR domains of SR proteins. The phosphorylation state controls the localisation of SR proteins, with hypo-phosphorylated SR proteins being more enriched in nuclear speckles. We identified a set of mRNAs that are bound by SR proteins in the nucleus, and we wondered whethe...
ORGANISM(S): Homo sapiens 
2025-07-29 | E-MTAB-13328 | biostudies-arrayexpress
UnknownStructure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases.
Not available
S-EPMC9571063 | biostudies-literature
Genomics3' sequencing of nuclear and cytoplasmic fractions following treatment with a CLK inhibitor
3' sequencing of nuclear and cytoplasmic fractions following treatment with a CLK inhibitor
PRJEB65860 | ENA
UnknownSGC-CLK-1: A chemical probe for the Cdc2-like kinases CLK1, CLK2, and CLK4.
Not available
S-EPMC10673624 | biostudies-literature
ProteomicsA novel class of CLK kinases inhibitors that target SRSF10 and promote p53mediated cytotoxicity on human colorectal cancer cells
The elevated expression of the splicing regulator SRSF10 in metastatic colorectal cancer (CRC) stimulates the production of the pro-tumorigenic Bclaf1-L splice variant. We discovered a group of small molecules with an aminothiazole carboxamide core (GPS167, GPS192 and others) that decrease productio...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022333 | Pride
Clk kinases inhibitor Srsf10 Human colorectal cancer cells 
UnknownDifferential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy.
Not available
S-EPMC3148977 | biostudies-literature
UnknownAnti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.
Not available
S-EPMC5991599 | biostudies-literature
ProteomicsMIB/MS determines SCH772984 is a selective ERK1/2 inhibitor in pancreatic cancer cells
Mutational activation of the KRAS oncogene is a major genetic driver of pancreatic ductal adenocarcinoma (PDAC) growth. KRAS-dependent PDAC growth is mediated primarily through persistent activation of the RAF-MEK-ERK mitogen-activated protein kinase (MAPK) cascade, one of the most extensively studi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD043585 | Pride
Erk Mib/ms Kinases Pancreatic cancer 
UnknownA triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.
Not available
S-EPMC5295499 | biostudies-literature
UnknownMolecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.
Not available
S-EPMC5933782 | biostudies-literature
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