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ProteomicsMIB-MS analysis of MERS-CoV and SARS-COV-2 infected cells.
Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress response to viral infection, and inflammation. Previous work has demonstrated coronaviruses specifically target kinase cascades to subvert host cell responses to infection and rely upon host kinase activity...
ORGANISM(S): Homo sapiens (Human) 
2023-08-01 | PXD040901 | Pride
Mib-ms  kinases  kinome  coronavirus  mers-cov  sars-cov-2  lfq quantitation  dda  lc-ms/ms. 
ProteomicsDetermining MELK inhibitor specificity using MIB/MS
The key objectives of this study were to evaluate the selectivity profiles of three MELK inhibitors, 8a, HTH, and OTS, using a cell-based assay, in order to identify a highly selective inhibitor to subsequently investigate MELK function. To this end, we utilized a chemical proteomics approach called...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016022 | Pride
Chemoproteomics Lfq Kinase enrichment 
ProteomicsMIB/MS determines SCH772984 is a selective ERK1/2 inhibitor in pancreatic cancer cells
Mutational activation of the KRAS oncogene is a major genetic driver of pancreatic ductal adenocarcinoma (PDAC) growth. KRAS-dependent PDAC growth is mediated primarily through persistent activation of the RAF-MEK-ERK mitogen-activated protein kinase (MAPK) cascade, one of the most extensively studi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD043585 | Pride
Erk Mib/ms Kinases Pancreatic cancer 
ProteomicsKinase Selectivity Profiling of anti-MRSA Diarylimidazoles in HEK293 Cells
Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it challenging to generate much-needed medicines. As an alternative discovery approach, a small array of diarylimidazoles was screened against the ESK...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040208 | Pride
Diarylimidazole Mib-ms Kinases Hek293 Antimicrobials 
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015783 | Pride
Human High-grade serous ovarian carcinoma Mrcka Cdc42bpa 
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015781 | Pride
Human Mrcka High grade serous ovarian carcinoma Cdc42bpa 
ProteomicsKinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 As A Candidate Therapeutic Target
Protein kinases (collectively termed the kinome) represent one of the most tractable drug targets in the pursuit of new and effective cancer treatments. However, less than 20% of the kinome is currently being explored as primary targets for cancer therapy, leaving the majority of the kinome untarget...
ORGANISM(S): Homo sapiens (Human) 
2020-09-30 | PXD020357 | Pride
Endometrial Srpk1 
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015849 | Pride
Human Mrcka High grade serous ovarian carcinoma Cdc42bpa 
ProteomicsKinome profiling upon HCMV infection using the MIB-MS approach
Human cytomegalovirus (HCMV) is a significant cause of disease in immune-compromised adults and immune naïve newborns. No vaccine exists to prevent HCMV infection, and current antiviral therapies have toxic side effects that limit the duration and intensity of their use. There is thus an urgent need...
ORGANISM(S): Homo sapiens (Human) 
2017-03-20 | PXD005276 | Pride
Hcmv Human herpesvirus Kinase inhibitors Kinome Antivirals Virology Label-free quantitation 
ProteomicsCompetitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits Glycogen Synthase Kinase 3 Beta and Activates WNT Signaling
The cellular and organismal phenotypic response to a small molecule kinase inhibitor is defined collectively by the inhibitor’s targets and their functions. The selectively of small molecule kinase inhibitors is commonly determined in vitro, using purified kinases and substrates. Recently, competiti...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-12-07 | PXD006139 | Pride
Polypharmacology Gsk3β Wnt signaling Kinase Chemoproteomics 
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