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MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
TranscriptomicsGene expression signature-based screening identifies new broadly effective influenza antivirals
Classical antiviral therapy inhibit viral proteins and are subject to resistance. To counteract this emergence, alternative strategy has been developed that target cellular factors. We hypothesized that such approach could also be useful to identify broad antivirals. Influenza A virus was used as a ...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-22319 | biostudies-arrayexpress
GenomicsGene expression of MDCK cells with antivirals treatment
Gene expression of MDCK cells with antivirals treatment
PRJNA971194 | ENA
GenomicsGene expression of Vero E6 cells with antivirals treatment
Gene expression of Vero E6 cells with antivirals treatment
PRJNA799311 | ENA
TranscriptomicsGene expression of MDCK cells with antivirals treatment
In addition to directly inhibiting viral proteins, some antiviral drugs inhibit virus replication through regulation of host gene expression. Here we test whether antiviral activity of antivirals is independent of modulating gene expression in infected host cells.
ORGANISM(S): Canis lupus familiaris 
2023-07-17 | GSE232189 | GEO
TranscriptomicsGene expression of Vero E6 cells with antivirals treatment
In addition to directly inhibiting viral proteins, some antiviral drugs inhibit virus replication through regulation of host gene expression. Here we test whether antiviral activity of antivirals is independent of modulating gene expression in infected host cells.
ORGANISM(S): Chlorocebus sabaeus 
2022-12-01 | GSE194130 | GEO
TranscriptomicsGene expression signature-based screening identifies new broadly effective influenza antivirals
Classical antiviral therapy inhibit viral proteins and are subject to resistance. To counteract this emergence, alternative strategy has been developed that target cellular factors. We hypothesized that such approach could also be useful to identify broad antivirals. Influenza A virus was used as a ...
ORGANISM(S): Homo sapiens 
2011-03-22 | GSE22319 | GEO
ProteomicsKinome profiling upon HCMV infection using the MIB-MS approach
Human cytomegalovirus (HCMV) is a significant cause of disease in immune-compromised adults and immune naïve newborns. No vaccine exists to prevent HCMV infection, and current antiviral therapies have toxic side effects that limit the duration and intensity of their use. There is thus an urgent need...
ORGANISM(S): Homo sapiens (Human) 
2017-03-20 | PXD005276 | Pride
Hcmv Human herpesvirus Kinase inhibitors Kinome Antivirals Virology Label-free quantitation 
ProteomicsGeneration of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics
Targeted protein degradation (TPD), as exemplified by proteolysis-targeting chimera (PROTAC), is a prominent paradigm in drug discovery. In this study, we applied conventional and novel PROTAC approaches to develop broad-spectrum antivirals (targeting key host factors for many different viruses) and...
ORGANISM(S): Homo sapiens (Human) 
2023-06-15 | PXD042352 | Pride
Protac  influenza  sars-cov-2  cmv  gspt1  oligonucleotide  antiviral therapeutics 
GenomicsAntiviral efficacy versus host recovery: contrasting transcriptional footprints of four antivirals in human cytomegalovirus-infected brain organoids
RNAseq of HCMV-infected cerebral organoids treated with four different antivirals
PRJEB106831 | ENA
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