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ProteomicsMablango_ClpP_HYTANE_P124_Lumos
This dataset consists of 6 raw MS files, acquired on Thermo Fusion Lumos mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Keith Wong. Sample processing and mass spectrometry acquisition was performed by Cassandra Wong. Data analysis was performed by Cassandra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-13 | MSV000089642 | MassIVE
TranscriptomicsExpression data from mitochondrial protease ClpP knock-out mice.
The peptidase ClpP is conserved from bacteria to human. In the mitochondrial matrix, it multimerizes and forms a macromolecular proteasome-like cylinder. Because of its known relevance for the mitochondrial unfolded protein response during cell stress, we characterized two ClpP knock-out mouse found...
ORGANISM(S): Mus musculus 
2013-07-17 | E-GEOD-40207 | biostudies-arrayexpress
ProteomicsMurine CLPP protease substrate trapping in MEF cells
Classic susbtrate-trapping screen for ClpXP substrates using MEF cell lines overexpressing FLAG-tagged CLPP (WT), proteolytically inactive CLPP (TRAP) or vector control (NEG)
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD015399 | Pride
Interactor Mouse Cllp protease Substrate Trap experiment Cell line 
ProteomicsImipridones cause cellular toxicity in human cells and bacteria by ectopic activation of the ClpP protease
Ectopic activation of the conserved ClpP protease by chemical activators causes toxicity in bacteria and human cells due to unrestrained proteolysis. The imipridone ONC201 has been ascribed multiple mechanisms of action and is currently in cancer clinical trials. To systematically investigate the ge...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2020-03-26 | PXD016119 | Pride
Imipridones Clpp protease 
ProteomicsBacillus subtilis ClpP degradome
To characterize the proteins substrates and the modifications of the ClpP protease of Bacillus subtilis.
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2016-10-10 | PXD003305 | Pride
Clpp Protein degradation Phosphoarginine 
ProteomicsClpP protease modulates bacterial growth, stress response and bacterial virulence in Brucella abortus
Intracellular proteolysis via ATP-dependent proteases is a conserved biological process. The ATP-dependent Clp protease is made up of peptidase ClpP and ATP-dependent chaperones and plays an important role in the proteolysis process. In several pathogenic bacteria, the Clp protease is implicated in ...
ORGANISM(S): Brucella abortus (strain 2308) 
2023-10-24 | PXD034842 | Pride
Virulence Itraq analysis Brucella Clpp protease 
ProteomicsiTRAQ analysis of ClpP mutant treated with methyl gallate
Methyl gallate (MG) is an effective microbicide with great potential usefulness in the integrated management of plant diseases and an important potential drug for clinical application. However, its target remains unknown. This study conducted a transposon sequencing (Tn-seq) under MG treatment in pl...
ORGANISM(S): Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) 
2020-12-10 | PXD021102 | Pride
Methyl gallate Ralstonia solanacearum Clpp protease 
ProteomicsProteomics and phosphoproteomics analysis of SUM159 cells upon ClpP activation with ONC201 and TR57 compounds
ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in an array of in vitro and in vivo studies, including clinical trials for refractory solid tumors. Though progress has been made in identifying specific phenot...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038990 | Pride
Drug development Drug mechanism Cancer Clpp 
ProteomicsDegradomics study of the mouse heart Clpp protease
Differential proteolytic processing in control and mitochondrial clpp protease-deficient mice were compared.
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD014159 | Pride
Clpp mouse heart protease degradomics tails 
GenomicsImipridone anticancer compounds ectopically activate the ClpP protease and represent a new scaffold for antibiotic development
Imipridone anticancer compounds ectopically activate the ClpP protease and represent a new scaffold for antibiotic development
PRJNA577699 | ENA
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