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TranscriptomicsGene expression profile in the cochlear tissue of Cmah-null mouse
CMP-Neu5Ac hydroxylase (Cmah) disruption caused several abnormalities and diseases including hearing loss in old age. However, underling molecular mechanisms that give rise to age-related hearing loss (AHL) in Cmah-null mouse are still obscure. To identify differential gene expression profiles asso...
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-70659 | biostudies-arrayexpress
ProteomicsCharacterisation of prostate cancer sialome re-engineering via CMAH transfection
This study investigated sialome re-engineering in prostate cancer cells following transfection with the rat Cmah gene, which encodes cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH). Expression of rat CMAH enables the conversion of CMP-Neu5Ac to CMP-Neu5Gc. Glycoproteomic analysis w...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD084162 | Pride
Lncap Cmah Neu5gc Neu5a 
TranscriptomicsGene expression profile of the Cmah gene depletion on mouse liver, lung, kidney and heart
N-glycolylneuraminic acid (Neu5Gc) is generated by hydroxylation of CMP-Neu5Ac to CMP-Neu5Gc, catalyzed by CMP-Neu5Ac hydroxylase (CMAH). However, humans lack this common mammalian cell surface molecule, Neu5Gc, due to inactivation of the CMAH gene during evolution. CMAH is one of several human-spec...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-59964 | biostudies-arrayexpress
TranscriptomicsArray profiling of dystrophin-deficient mice with a secondary glycosylation defect
A deletion in the CMAH gene in humans occurred approximately 3.5 million years ago. This resulted in the inactivation of the CMP-Neu5Ac hydroxylase enzyme, and hence, in the specific deficiency in N-glycolylneuraminic acid (Neu5Gc), a form of sialic acid, in all modern humans. Although there is evid...
ORGANISM(S): Mus musculus 
2010-07-31 | E-GEOD-16438 | biostudies-arrayexpress
TranscriptomicsGene expression profile in the cochlear tissue of Cmah-null mouse
CMP-Neu5Ac hydroxylase (Cmah) disruption caused several abnormalities and diseases including hearing loss in old age. However, underling molecular mechanisms that give rise to age-related hearing loss (AHL) in Cmah-null mouse are still obscure. To identify differential gene expression profiles assoc...
ORGANISM(S): Mus musculus 
2015-07-10 | GSE70659 | GEO
TranscriptomicsGene expression profile of the Cmah gene depletion on mouse liver, lung, kidney and heart
N-glycolylneuraminic acid (Neu5Gc) is generated by hydroxylation of CMP-Neu5Ac to CMP-Neu5Gc, catalyzed by CMP-Neu5Ac hydroxylase (CMAH). However, humans lack this common mammalian cell surface molecule, Neu5Gc, due to inactivation of the CMAH gene during evolution. CMAH is one of several human-spec...
ORGANISM(S): Mus musculus 
2014-08-01 | GSE59964 | GEO
GenomicsPotential Antigens Involved In Delayed Xenograft Rejection in a GGTA1/CMAH DKO Pig-To-Monkey Model
Potential Antigens Involved In Delayed Xenograft Rejection in a GGTA1/CMAH DKO Pig-To-Monkey Model
PRJNA390077 | ENA
UnknownPhylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc.
Not available
S-EPMC5767959 | biostudies-literature
UnknownEvaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes.
Not available
S-EPMC4464961 | biostudies-literature
UnknownHuman-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution.
Not available
S-EPMC6158528 | biostudies-literature
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