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ProteomicsMcm7 ubiquitylation and Pif1-family helicases drive CMG disassembly to preserve genome integrity
Disassembly of the DNA helicase known as CMG (Cdc45-Mcm-GINS) is the key regulated step during DNA replication termination in eukaryotes. In budding yeast, CMG disassembly is initiated by the ubiquitin ligase SCF-Dia2, which ubiquitylates the Mcm7 subunit of CMG, leading to recruitment of the Cdc48...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-04-09 | PXD048935 | Pride
Ubiquitylation Dia2 Cmg helicase Cmg disassembly Pif1 S. cerevisiae Dna replication Rrm3 
UnknownCMG helicase disassembly is essential and driven by two pathways in budding yeast.
Not available
S-EPMC11405719 | biostudies-literature
UnknownCMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold.
Not available
S-EPMC7462611 | biostudies-literature
UnknownUfd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication.
Not available
S-EPMC5382235 | biostudies-literature
UnknownTethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase.
Not available
S-EPMC4562905 | biostudies-literature
UnknownIn Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast.
Not available
S-EPMC6899518 | biostudies-literature
UnknownCdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication.
Not available
S-EPMC4300516 | biostudies-literature
UnknownCUL2<sup>LRR1</sup> , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle.
Not available
S-EPMC7926238 | biostudies-literature
ProteomicsCRL2LRR1 is required for CMG unloading during vertebrate replication termination
A key event during eukaryotic replication termination is the removal of the CMG helicase from chromatin. CMG unloading involves ubiquitylation of its MCM7 subunit and the action of the p97 ATPase. Using a proteomic screen in Xenopus egg extracts, we identified factors that are retained on chromatin...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2017-02-02 | PXD004828 | Pride
Chromass Dna replication termination Cullin e3 ligases Xenopus egg extracts 
UnknownReconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.
Not available
S-EPMC8331092 | biostudies-literature
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