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MetabolomicsIn-depth characterization of the CaV2.2-knockout mouse line

ABSTRACT The voltage-gated calcium channel CaV2.2 is predominantly located in neuronal synapses, where it plays a role in pain signaling and neurotransmitter release. Furthermore, CaV2.2 is important during early central nervous system development, as it is subsequently replaced by other calcium ...

2026-07-09 | MTBLS14319 | MetaboLights
TranscriptomicsTranscriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation
One of the key aspects of neuronal differentiation is the array of neurotransmitters and neurotransmitter receptors that each neuron possesses. One important goal of developmental neuroscience is to understand how these differentiated properties are established during development. In this paper, we ...
ORGANISM(S): Drosophila melanogaster 
2012-10-12 | E-GEOD-41510 | biostudies-arrayexpress
TranscriptomicsGEP of the murine cell line BAL17 (BALB/c)
GEP of the murine cell line BAL17 (BALB/c) BAL17- / BAL17VII-induced primary CNS lymphoma analysis. 5x10^5 cells were implanted into the brain of BALB/c wt mice and analyzed 21 and 28 days post implantation. The cell lines were also analyzed.
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-38675 | biostudies-arrayexpress
ProteomicsIn-depth characterization of the secretome of mouse CNS cell lines by LC-MS/MS without prefractionation
Microglia, astrocytes, and neurons, which have important functions in the central nervous system, communicate mutually to generate a signal through secreted proteins or small molecules, but many of which have not been identified. Because establishing a reference for the secreted proteins from CNS ce...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD001597 | Pride
Neuron Cns cell line Proteome profile Microglia Label-free quantitation Secretome Astrocyte 
ProteomicsD283 MED, a cell line derived from peritoneal metastatic medulloblastoma — a good choice for missing protein discovery
Our goal is the identification of more and more missing proteins from cancer cell lines. This project focuses on D283 med and U-118mg cell lines which contribute to 12 missing protein identification.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-21 | MSV000087678 | MassIVE
TranscriptomicsImpaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
In the course of primary infection with herpes simplex virus 1 (HSV-1), children with inborn errors of the TLR3- and UNC-93B-dependent induction of IFN-α/β and/or IFN-λ immunity are prone to HSV-1 encephalitis (HSE) 1-3. The cells responsible for HSE in these children have yet to be identified. We t...
ORGANISM(S): Homo sapiens 
2012-11-29 | E-GEOD-40593 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of single cells of the oligodendrocyte lineage from nine distinct regions of the anterior-posterior and dorsal-ventral axis of the mouse juvenile central nervous system
5069 transcriptomes of single oligodendrocyte cells from spinal cord, substantia nigra-ventral tegmental area, striatum, amygdala, hypothalamic nuclei, zona incerta, hippocampus, and somatosensory cortex of male and female mice between post-natal day 21 and 90. The study aimed at identifying diverse...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-75330 | biostudies-arrayexpress
ProteomicsThe value of subcellular fractionation for protein identification in a B-cell line (Ramos)
Integrated in the Chromosomic-centric Human Proteome Project (C-HPP), a lymphocytic B-cell line (Ramos) was selected as a model of B-cells. We performed a subfractionation strategy (in triplicate) for the extraction of proteins from 4 different fractions (cytoplasm, CYT; organella, ORG; membrane, MB...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079936 | MassIVE
Transcriptomicsgene expression profiling of brain metastatic melanoma cell lines
Cerebral metastases occur in a majority of metastatic melanoma patients and are a major cause of mortality. Despite this, there is a poor understanding of the molecules/pathways that lead to the brain-metastatic phenotype. Studies designed to address this deficiency and test novel therapeutic approa...
ORGANISM(S): Homo sapiens 
2012-11-21 | E-GEOD-23601 | biostudies-arrayexpress
TranscriptomicsDysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects of damage to oligodendrocytes and failure of remyelination. A common feature of demyelinated lesions is the presence of oligodendrocyte precursors (OLPs) blocked at a pre...
ORGANISM(S): Mus musculus 
2009-12-10 | E-GEOD-19403 | biostudies-arrayexpress
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