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ProteomicsCo-translational assembly counteracts promiscuous interactions
During the co-translational assembly of protein complexes, a fully synthesized subunit engages with the nascent chain of a newly synthesized interaction partner. Such events are thought to contribute to productive assembly, but their exact physiological relevance remains underexplored. Here, we exam...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-11 | PXD030626 | Pride
Co-translational assembly Proteomics 
ProteomicsCo-translational assembly counteracts promiscuous interactions
During the co-translational assembly of protein complexes, a fully synthesized subunit engages with the nascent chain of a newly synthesized interaction partner. Such events are thought to contribute to productive assembly, but their exact physiological relevance remains underexplored. Here, we exam...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-11 | PXD028413 | Pride
Protein complex assembly Co-translational assembly Nuclear pore complex 
GenomicsCo-translational assembly counteracts promiscuous interactions - addendum
Co-translational assembly counteracts promiscuous interactions - addendum
PRJEB50305 | ENA
ProteomicsCo-translational determination of quaternary structures in chaperone factories
The HSP90/R2TP quaternary chaperone assembles key cellular machines, including the three nuclear RNA polymerases and many non-coding RNPs. Here, we show that the R2TP binds many partners co-translationally. Remarkably, its co-translational interactome reveals many novel potential clients, and side-b...
ORGANISM(S): Homo sapiens (Human) 
2026-01-06 | PXD061298 | Pride
Translation factories Chaperone Co-translational assembly 
ProteomicsHierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID
Large heteromeric multiprotein complexes play pivotal roles at every step of gene expression in eukaryotic cells. Among them, the 20-subunits basal transcription factor TFIID nucleates RNA polymerase II preinitiation complex at gene promoters. Here, by combining systematic RNA-immunoprecipitation ex...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD036358 | Pride
Taf1-dependent co-translational assembly of tfiid 
UnknownCo-translational assembly orchestrates competing biogenesis pathways.
Not available
S-EPMC8907234 | biostudies-literature
GenomicsCo-translational determination of quaternary structures in chaperone factories
Co-translational determination of quaternary structures in chaperone factories
PRJNA1235270 | ENA
UnknownCo-translational assembly of mammalian nuclear multisubunit complexes.
Not available
S-EPMC6465333 | biostudies-literature
GenomicsCo-translational ribosome pairing enables native assembly of misfolding-prone subunits
Co-translational ribosome pairing enables native assembly of misfolding-prone subunits
PRJNA1191379 | ENA
ProteomicsN-terminal acetylation of yeast NAT-A mutants
Protein-protein interactions are fundamental to all cellular activities, with the ribosome increasingly recognized as a central platform steering the dynamics of nascent-chain interactions. In our focus on conserved N-terminal acetyltransferases (NATs), we identified distinct co-translational assemb...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-06-22 | PXD048082 | Pride
N-terminal acetylation Naa15 Naa10 Co-translational assembly Terminomics 
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