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ProteomicsLC-MS/MS analysis of immunoprecipitated NAA15-V5 variants
The human N-terminal acetyltransferase E (NatE) including its associated NatA co-translationally acetylates the N-terminus of about 40-60% of the proteome to mediate diverse biological processes including protein half-life, localization and protein interaction. In eukaryotes, the NatE complex contai...
ORGANISM(S): Homo sapiens (Human) 
2020-03-13 | PXD017031 | Pride
Lc-ms/ms N-terminal acetylation Nate Naa15 Naa10 Hypk Naa50 
ProteomicsChaetomium thermophilum Naa50 and Naa15 TMT-labeled LC-MSMS
TMT-labeled LC-MSMS was performed to identify and quantify proteins from three different TAP-purification pull-outs from Chaetomium thermophilum. The aim was to identify interaction partners and to study, whether the two tagged proteins (Naa50 and Naa15) are likely to interact, as they do in other o...
ORGANISM(S): Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 
2022-10-14 | PXD035320 | Pride
Naa50 naa15 lc-msms tmt chaetomium thermophilum 
ProteomicsLC-MS/MS analysis of NAA15 and NAA10 IP
LC-MS/MS analysis of endogenous NAA15 and NAA10 immunoprecipitated from HeLa cell lysates was performed to identify cellular binding partners.
ORGANISM(S): Homo sapiens (Human) 
2025-12-17 | PXD059724 | Pride
N-terminal acetylation Nata Naa15 Naa10 
GenomicsNAA15 haploinsufficiency can cause congenital heart disease and perturbs protein levels in induced pluripotent stem cells
NAA15 haploinsufficiency can cause congenital heart disease and perturbs protein levels in induced pluripotent stem cells
PRJNA674581 | ENA
TranscriptomicsNAA15 haploinsufficiency can cause congenital heart disease and perturbs protein levels in induced pluripotent stem cells
Rationale- NAA15 is a component of the N-terminal (Nt) acetyltransferase complex, NatA. The mechanism by which NAA15 haploinsufficiency causes congenital heart disease (CHD) remains unknown. To better understand molecular processes by which NAA15 haploinsufficiency perturbs cardiac development, we i...
ORGANISM(S): Homo sapiens 
2020-11-05 | GSE160809 | GEO
ProteomicsMass-spectrometry based quantification of HYPK, NAA10 and NAA15 protein steady-state levels in Arabidopsis thaliana mutants carrying a T-DNA insertion in the HYPK gene.
N-alpha terminal acetylation is one of the major protein modifications in eukaryotes carried out by distinct Nats (N-alpha acetyltransferases). The core NatA complex is composed of the catalytic NAA10 and the auxiliary NAA15 subunit and co-translationally acetylates majority of the cytosolic protein...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-08-12 | PXD023599 | Pride
Arabidopsis thaliana Hypk Nata complex N-alpha terminal acetylation 
UnknownNeuroanatomical Features of NAA10- and NAA15-Related Neurodevelopmental Syndromes.
Not available
S-EPMC11230317 | biostudies-literature
UnknownExpanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome.
Not available
S-EPMC10325952 | biostudies-literature
ProteomicsNAA15 haploinsufficiency can cause congenital heart disease and perturbs protein levels in induced pluripotent stem cells
NAA15 is a component of the NatA complex that acetylates amino terminal (Nt) protein residues and influences protein synthesis. We identified multiple damaging NAA15 variants in congenital heart disease patients, including four loss-of-function (LoF) variants, one missense (R276W) de novo variant an...
ORGANISM(S): Homo sapiens (Human) 
2021-08-30 | PXD018013 | Pride
Ipsc N-terminal acetylation N-terminomics 
ProteomicsNAA15 haploinsufficiency can cause congenital heart disease and perturbs protein levels in induced pluripotent stem cells
NAA15 is a component of the NatA complex that acetylates amino terminal (Nt) protein residues and influences protein synthesis. We identified multiple damaging NAA15 variants in congenital heart disease patients, including four loss-of-function (LoF) variants, one missense (R276W) de novo variant an...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD017672 | Pride
Ipsc Shotgun proteomics Lc-ms/ms 
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