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MetabolomicsClinical features and Multiomics Profiles Indicate Coagulation and Platelet Dysfunction as Key Pathological Pathways in COVID-19 Viral Sepsis
Background: The role of viral infections as a mediator of systemic immune dysfunction leading to sepsis has received limited attention compared to the bacterial pathogens. The COVID-19 pandemic and the increased cases of sepsis in the absence of known bacterial pathogens have highlighted the clinica...
2025-12-05 | MTBLS9664 | MetaboLights
TranscriptomicsVirus-misplaced host protein activates innate immunity
Discrimination between self vs. non-self and adequate response to infection and tissue damage are fundamental functions of the immune system. The rapid and global spread of known and emerging viruses is a testament that the timely detection of viral pathogens that reproduce within host cells, presen...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-36078 | biostudies-arrayexpress
ModelsXu2002 - Blood Coagulation Model of Activated Factors with Platelet Activation
System of ODEs to describe the dynamics of several activated factors of blood coagulation. Publication introduces a platelet activation term for synthesis of Xa and IIa.
2018-06-13 | MODEL1806130001 | BioModels
ModelsXu2005 - Blood Coagulation Model of Activated Factors of Extrinsic Pathway and TFPI
System of ODEs to describe the behaviour of the activated factors of the extrinsic pathway of blood coagulation with the addition of the TFPI-Xa complex. Mass-action kinetics used with the only exception of factor IIa production (Michaelis-Menten rate law).
2018-06-13 | MODEL1806130002 | BioModels
ModelsNayak2015 - Blood Coagulation Network - Predicting the Effects of Various Therapies on Biomarkers
Nayak2015 - Blood Coagulation Network - Predicting the Effects of Various Therapies on Biomarkers Note: The SBML model is generated from SimBiology. The SimBiology (.sbproj) file is available for download from the curation tab. This model is des...
2024-09-02 | BIOMD0000000611 | BioModels
UnknownCoagulation and platelet function in cold-stored whole blood on missions in a helicopter emergency service.
Not available
S-EPMC11744058 | biostudies-literature
UnknownUrinary extracellular vesicles carry multiple activators and regulators of coagulation.
Not available
S-EPMC9489905 | biostudies-literature
ProteomicsSelf-anticoagulant sponges for whole blood auto-transfusion and its mechanism of coagulation factor inactivation
Clinical use of intraoperative auto-transfusion requires the removal of platelets and plasma proteins due to the pump-based suction and water-soluble anticoagulant administration, which causes dilutional coagulopathy. Herein, we develop a carboxylated and sulfonated heparin-mimetic polymer-modified ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-23 | PXD044005 | Pride
Anticoagulation  coagulation factor inactivation  whole blood auto-transfusion 
ProteomicsProteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases
Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are leading causes of visual impairment and blindness in people aged 50 years or older in middle-income and industrialized countries. Anti-VEGF therapies have improved the management of neovascular AMD (nAMD) and proliferative DR (...
ORGANISM(S): Homo sapiens (Human) 
2023-03-09 | PXD038285 | Pride
Complement and coagulation cascades Age-related macular degeneration Neurodegeneration Vitreous proteomics. Extracellular matrix Proliferative diabetic retinopathy Biomarkers Retinal detachment 
UnknownCryo-EM structures of coagulation factors.
Not available
S-EPMC9630041 | biostudies-literature
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