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TranscriptomicsCodY of Streptococcus pneumoniae: link between nutritional gene regulation and virulence
CodY is a nutritional regulator mainly involved in amino acid metabolism. It has been extensively studied in Bacillis subtilis and Lactococcus lactis. We investigated the role of CodY in gene regulation and virulence of the human pathogen Streptococcus pneumoniae. We constructed a codY-mutant and ex...
ORGANISM(S): Streptococcus pneumoniae TIGR4 
2010-05-25 | E-GEOD-7350 | biostudies-arrayexpress
TranscriptomicsMultiple roles for CodY in the type strain Bacillus cereus ATCC 14579
Comparison of the B cereus codY deletion mutant with wild type strain (ATCC 14579) One condition design comparision of mutant vs wild type including a dye swap, 4 biological replicate
ORGANISM(S): Bacillus cereus ATCC 14579 
2012-07-04 | E-GEOD-31017 | biostudies-arrayexpress
MetabolomicsInterplay of CodY and CcpA in regulating central metabolism and biofilm formation in S. aureus
Not available
ORGANISM(S): Staphylococcus aureus 
ST002187 | MetabolomicsWorkbench
TranscriptomicsCodY in Staphylococcus aureus: regulatory link between metabolism and virulence gene expression
CodY is a conserved regulator in gram-positive organisms described to repress metabolic genes mainly involved in nitrogen metabolism but also to control the expression of virulence genes in pathogens. We constructed codY gene-replacement mutants in three unrelated S. aureus strains (Newman, UAMS-1, ...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2008-11-06 | E-GEOD-12340 | biostudies-arrayexpress
TranscriptomicsCounteractive balancing of transcriptome expression involving CodY and CovRS in Streptococcus pyogenes
Streptococcus pyogenes (group A Streptococcus, GAS) responds to environmental changes in a manner that results in an adaptive regulation of the transcriptome. Global transcriptional regulators are able to integrate important extracellular and intracellular information and are responsible for modulat...
ORGANISM(S): Streptococcus pyogenes NZ131 
2011-03-01 | E-GEOD-26590 | biostudies-arrayexpress
GenomicsSystems level analyses establish CodY as a multifaceted metabolic regulator integrating metabolism, motility and virulence in Listeria monocytogenes [ChIP-Seq]
To gain knowledge on L. monocytogenes differential CodY activity, we set on analyzing CodYâ??s regulon in L. monocytogenes in both rich and minimal growth conditions using genome wide sequencing techniques. Remarkably, we identified for the first time a global regulatory role for CodY when BCAAs are...
ORGANISM(S): Listeria monocytogenes 
2016-07-03 | E-GEOD-76821 | biostudies-arrayexpress
TranscriptomicsThe CodY Regulon in Streptoccus mutans
In this report, codY mutant strains were constructed and used to demonstrate the relationship of (p)ppGpp synthesized by RelP and RelQ with the activation of CodY. In addition, because CodY has not been studied in S. mutans, we used microarrays to demonstrate that this protein function as a global ...
ORGANISM(S): Streptococcus mutans 
2010-05-17 | E-GEOD-9641 | biostudies-arrayexpress
ProteomicsCodY regulates the activity of the virulence quorum sensor PlcR
In Gram-positive bacteria, cell-cell communication mainly relies on cytoplasmic sensors of the RNPP family. Activity of these regulators depends on their binding to secreted signaling peptides that are imported into the cell. These quorum sensing regulators control important biological functions in ...
ORGANISM(S): Bacillus thuringiensis Bt407 
2015-12-17 | PXD003311 | Pride
Opp Bacillus Cody Mass spectrometry Plcr Signaling peptide Quorum-sensing Virulence regulon Shot gun Regulation 
TranscriptomicsTranscription profiling of B anthracis wild type and codY mutant 7CodYS
B. anthracis 7702 and the codY mutant 7CodYS were grown in R-medium (Ristroph, J.D. & Ivins, B.E. (1983). Elaboration of Bacillus anthracis antigens in a new, defined culture medium. Infect. Immun. 39:483-486) with 0.6% sodium bicarbonate until A600 = 0.2 or 1.0. The transcriptome of both strains wa...
ORGANISM(S): Bacillus anthracis 
2008-11-15 | E-MEXP-1706 | biostudies-arrayexpress
TranscriptomicsInvestigating the effect of CodY mutation on the gene expression in Streptococcus suis serotype 2 SC19 strain.
To investigate the effect of CodY mutation on the gene expression in Streptococcus suis serotype 2 SC19 strain, we have employed whole genome microarray expression profiling as a discovery platform to identify genes regulated by CodY mutation. DNA microarray analysis was performed using an Agilent c...
ORGANISM(S): Streptococcus suis 
2015-04-21 | E-GEOD-68068 | biostudies-arrayexpress
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