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ProteomicsNemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells
The Foxp3 transcription factor is a crucial determinant of both regulatory T (TREG) cell development and their functional maintenance. Appropriate modulation of tolerogenic immune responses therefore requires tight regulation of Foxp3 transcriptional output, and this involves both transcriptional an...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-02 | PXD011164 | Pride
Nlk Ubiquitination Phosphorylation Foxp3 Nlk Tcr Immune tolerance Regulatory t cell 
ProteomicsA metabolism-epigenome axis controls early events in CD4+ T cell activation
Upon antigen-specific T Cell Receptor (TCR) engagement, human CD4+ T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming utilizing aerobic glycolysis together with maintenance of oxidative phosphorylation1,2. However, the role of g...
ORGANISM(S): Homo sapiens (Human) 
2023-10-27 | PXD018132 | Pride
Human cd4+ t cells Antigen-specific t cell receptor (tcr) engagement 
GenomicsPol2Chip
Pol2
EGAD00010000860 | EGA
GenomicsH3K27me3Chip
H3K27me3
EGAD00010000862 | EGA
Genomicsena-DATASET-CRUK-CI-11-11-2015-15:28:33:473-12 - samples
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
EGAD00001001668 | EGA
GenomicsExpression
Expression Arrays
EGAD00010000867 | EGA
GenomicsH3K27AcChip
H3K27Ac
EGAD00010000863 | EGA
GenomicsMBDSEQ
MBDSEQ
EGAD00010000865 | EGA
Genomicsena-DATASET-CRUK-CI-11-11-2015-14:57:45:115-9 - samples
Data from the paper Context-specific Effects of TGFβ/SMAD3 in Cancer Are Modulated by the Epigenome. Tufegdzic et al, Cell Reports 2015
EGAD00001001667 | EGA
GenomicsAza
Targeted bisulfite sequencing
EGAD00010000868 | EGA
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