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To investigate whether MELK phosphorylates Cofilin-1 at residue Threonine 70 (T70), we performed a phosphoproteomic validation using immunoprecipitation coupled with mass spectrometry (IP-LC-MS/MS). HEK293T cells were divided into three experimental groups: (1) MOCK control (Empty Vector), (2) MELK ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD074164 | Pride
Expression data from heart expressing cofilin-1(Th25) variants
Small ubiquitin-like modifier (SUMO) typically conjugates to target proteins through isopeptide linkage to the ε-amino group of lysine residues. This posttranslational modification (PTM) plays pivotal roles in modulating protein function. As a key regulator of actin cytoskeleton dynamics, cofilins (...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD038392 | Pride
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