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ProteomicsIIS-mediated modulation of DIGs proteome in C. elegans.
Reducing insulin/IGF-1 signaling (IIS) extends lifespan, promotes protein homeostasis (proteostasis) and elevates stress resistance of worms, flies and mammals. How these functions are orchestrated across the organism is only partially understood. One prominent group of IIS-regulated encode for lipi...
ORGANISM(S): Caenorhabditis elegans 
2018-05-09 | PXD009704 | Pride
Detergent resistant granules. Aging Insulin/igf signaling C. elegans 
ProteomicsThe Insulin/IGF Signaling Cascade Modulates SUMOylation to Regulate Aging and Proteostasis in C. elegans.
In this project we asked how reducing the activity of the insulin/IGF signaling (IIS) cascade by knocking down the expression of daf-2, affects global protein SUMOylation of C. elegans. We found that among other proteins, IIS reduction lowers the SUMOylation of CAR-1, a protein that negatively regul...
ORGANISM(S): Caenorhabditis elegans 
2018-06-06 | PXD010011 | Pride
Sumoylation Aging Lifespan C. elegans Germline Insulin/igf signaling (iis) Proteostasis 
ProteomicsIsoflurane Aggravates Pre-Existing Proteotoxicity in Adult Nematodes by Suppressing Mitochondrial Fitness
Post operative delirium (POD) is an acute complication characterized by fluctuating attention and confusion which may develop and persist into cognitive decline. POD is most commonly observed in elderly patients, particularly those with preexisting cognitive impairments. Isoflurane, as a widely used...
ORGANISM(S): Caenorhabditis elegans 
2025-09-13 | PXD054547 | Pride
Proteostasis Proteotoxicity Mitochondria Aging Volatile anesthetics Delirium C. elegans 
ProteomicsCathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms
While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated in brains of AD patients. How CTSB exacerbates the toxicity ...
ORGANISM(S): Caenorhabditis elegans 
2024-09-03 | PXD045531 | Pride
Proteotoxicity Aging Cathepsin b Neurodegeneration 
ProteomicsCathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms
While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated in brains of AD patients. How CTSB exacerbates the toxicity ...
ORGANISM(S): Caenorhabditis elegans 
2024-09-03 | PXD045565 | Pride
Cathepsin activity Neurodegeneration C.elegans 
UnknownSafety of the PCSK9 inhibitor alirocumab: insights from 47 296 patient-years of observation.
Not available
S-EPMC11249957 | biostudies-literature
UnknownApolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
Not available
S-EPMC9422774 | biostudies-literature
UnknownLipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.
Not available
S-EPMC8822604 | biostudies-literature
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