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MetabolomicsCold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis
Vein occlusion (VO), including deep venous thrombosis (DVT) and retinal vein occlusion (RVO), is a common cause of multiple diseases that severely compromise the quality of life of affected individuals. Epidemiological evidence indicates that VO prevalence increases in cold seasons, yet the underlyi...
2026-07-08 | MTBLS14667 | MetaboLights
MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
MetabolomicsChilling-induced restructuring of seed-borne endophytes enhances early cold tolerance and microbiome assembly in common vetch
Chilling stress constitutes a major abiotic constraint on plant growth and productivity. Although plants mobilize well-characterized physiological and transcriptional acclimation mechanisms, the integrative roles of root-associated microbiomes and root exudate chemistry in chilling tolerance, partic...
2026-04-21 | MTBLS14339 | MetaboLights
MetabolomicsMouse Brown Adipose Tissue Lipidomics under Cold and Dietary Fat Interventions
This study investigates lipidomic remodeling in mouse brown adipose tissue under a 2 × 3 experimental design involving environmental condition and dietary fatty acid composition. Mice were maintained at room temperature with ad libitum feeding or exposed to 4°C cold conditions with 70% calorie restr...
2026-06-01 | MTBLS14642 | MetaboLights
ProteomicsUniversal plant phosphoproteomics workflow and its application to tomato signaling in response to cold stress
Phosphorylation-mediated signaling transduction plays a crucial role in the regulation of plant defense mechanisms against environmental stresses. To address the high complexity and dynamic range of plant proteomes and phosphoproteomes, we present a universal sample preparation procedure that facili...
ORGANISM(S): Solanum Pimpinellifolium Solanum Lycopersicum 
PXD010310 | JPOST Repository
TranscriptomicsIdentification of microRNAs involved in cold stress response in grapevine.
Two small RNA libraries were generated from micropropagated â??Muscat Hamburgâ?? (Vitis vinifera) plantlets under normal and low temperatures (4 °C). A total of 163 known miRNAs and 299 putative novel miRNAs were detected from two small RNA libraries by Solexa sequencing. Forty-four cold-inducible ...
ORGANISM(S): Vitis vinifera 
2016-06-14 | E-GEOD-68970 | biostudies-arrayexpress
TranscriptomicsThe cold-induced two-component system CBO0366/CBO0365 regulates metabolic pathways with novel roles in cold tolerance of Group I Clostridium botulinum ATCC 3502
The two-component system CBO0366/CBO0365 was recently demonstrated to have a role in cold tolerance of Group I Clostridium botulinum ATCC 3502. The mechanisms under its control, ultimately resulting in increased sensitivity to low temperature, are unknown. A transcriptomic analysis with DNA microarr...
ORGANISM(S): Clostridium botulinum A str. ATCC 3502 
2013-10-29 | E-GEOD-26587 | biostudies-arrayexpress
ProteomicsMusa spp, LC-MSMS - Early Cold-Induced Peroxidases and Aquaporins Are Associated With High Cold Tolerance in Dajiao (Musa spp
Banana is an important tropical fruit with high value. One main specie (cultivar Cavendish) is susceptible to low temperature, another close relative specie (Dajiao), considerably higher cold tolerance than Cavendish. Our previous global proteomics results suggested that some membrane proteins be li...
ORGANISM(S): Musa acuminata x Musa textilis 
2018-10-23 | PXD007784 | Pride
Quantitative proteomics  cold tolerance  peroxidase  aquaporin 
TranscriptomicsGenome-wide Gene Expression Profiling Associated with Seedling Cold Tolerance Improvement in Japonica Rice Background
Rice in tropical and sub-tropical areas is often subjected to cold stress at the seedling stage resulting in poor growth and yield loss. In general, japonica rice has stronger cold tolerance (CT) than indica rice. However, several favorite alleles for CT exist in indica rice and can be used to enhan...
ORGANISM(S): Oryza sativa Japonica Group 
2012-12-31 | E-GEOD-37940 | biostudies-arrayexpress
TranscriptomicsTranslational profiling of HEK293 cells exposed to cold shock (32 degrees C) and untreated (37 degrees C)
This experiment investigates the effect of mild cold-shock (32 degrees C, 24 hours) on the translatome of human HEK293 cells. After cold-shock, cells were treated with cycloheximide to block elongation, then sucrose density gradients were used to separate post-nuclear extracts into polysome and subp...
ORGANISM(S): Homo sapiens 
2017-02-23 | E-MTAB-5437 | biostudies-arrayexpress
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