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ProteomicsIon channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies
Targeted protein degradation or downregulation (TPD/TPDR) mediated by induced recruitment of an endogenous E3 ubiquitin ligase to a substrate is a disruptive paradigm for developing therapeutics. However, <2% of ~600 E3 ligases have been exploited for this modality, and efficacy for multi-subunit me...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD069051 | Pride
Hek293 cells Nedd4-2 Divalent nanobody Ion channels 
ProteomicsDigly analysis of human Kv7.1 transfected in HEK293 cells. 
Polyubiquitin chain diversity generates a ‘ubiquitin code’ that universally regulates protein functional expression but functions of polyubiquitin diversity are mostly unknown. Using digly mass spectrometry, we have evaluated the basal polyubiquitin diversity on Kv7.1 ion channels expressed with a C...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD057805 | Pride
Kv7.1 ion channel Nedd4l Itch Polyubiquitin Protein degradation Ubiquitin code 
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