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ProteomicsProline hydroxylation of collagens in prolyl 4-hydroxylase mutant mice
Collagen from the skin of wild type and prolyl 4-hydroxylase mutant mice was extracted and proline hydroxylation of the collagen-derived peptides were analyzed by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2018-04-10 | PXD008802 | Pride
Mouse Collagen prolyl 4-hydroxylase 
ProteomicsSite-specific quantification of collagen post-translational modifications reveals profound disruption of the collagen biosynthetic network upon prolyl-3-hydroxylase 1 deficiency
Type I collagen is the main structural protein in mammals and other vertebrate life forms. During the biosynthesis of collagens, prolyl-3-hydroxylase 1 (P3H1) catalyzes 3-hydroxylation of proline residues and acts as a chaperone. Deficiency of P3H1 causes Osteogenesis Imperfecta (OI), a hereditary d...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-02 | PXD053751 | Pride
Glycosylation Collagen Tendon Post-translational modification (ptm) Prolyl-3-hydroxylase Hydroxyproline 
UnknownComplement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.
Not available
S-EPMC5612014 | biostudies-literature
UnknownMannose Binding Lectin Is Hydroxylated by Collagen Prolyl-4-hydroxylase and Inhibited by Some PHD Inhibitors.
Not available
S-EPMC8809307 | biostudies-literature
UnknownHuman Collagen Prolyl 4-Hydroxylase Is Activated by Ligands for Its Iron Center.
Not available
S-EPMC5141248 | biostudies-literature
UnknownTargeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth.
Not available
S-EPMC8887959 | biostudies-literature
UnknownCollagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance.
Not available
S-EPMC6203834 | biostudies-literature
UnknownCollagen Prolyl Hydroxylases Are Bifunctional Growth Regulators in Melanoma.
Not available
S-EPMC7015666 | biostudies-literature
UnknownCollagen prolyl 4-hydroxylase 2 predicts worse prognosis and promotes glycolysis in cervical cancer.
Not available
S-EPMC6895525 | biostudies-literature
UnknownSelective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells.
Not available
S-EPMC4798942 | biostudies-literature
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