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TranscriptomicsGene expression profiling of metastatic lung cancer cell lines
During malignant disease progression, the extracellular matrix (ECM) of epithelial tumors accumulates inter-molecular cross-links between collagen strands; these cross-links enhance ECM stiffness and trigger tumor cell invasion and dissemination, but the mechanisms that regulate intra-tumoral collag...
ORGANISM(S): Mus musculus 
2015-03-12 | E-GEOD-49315 | biostudies-arrayexpress
TranscriptomicsECM-dependent gene expression in normal and tumor-derived mammary organoids
A critical step in metastasis is cancer cell dissemination. Dissemination and metastasis are associated with specific genetic changes and changes in extracellular matrix (ECM), but how these changes interact to enable dissemination remains unclear. Here we tested the importance of ECM to disseminat...
ORGANISM(S): Mus musculus 
2012-08-16 | E-GEOD-39173 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human glioblastoma cell line U87 cell spheroids before and after migration on collagen
U87 cell spheroids were harvested from collagen on day 0 (no migration), or day 3 (extensive migration). The RNA extracted from these cells was used to identify microRNA alterations that occur during glioma cell line migration.
ORGANISM(S): Homo sapiens 
2010-01-28 | E-MEXP-2567 | biostudies-arrayexpress
ProteomicsProteomic characterization of extracellular matrix (ECM) produced by human fibroblast activation protein (FAP)-positive pericyte-like cells and glioma cells
Fibroblast activation protein (FAP) is upregulated in most cancers and represents an emerging theranostic target in oncology. In glioblastoma (GBM), FAP is predominantly expressed in mesenchymal pericyte-like cells, which contribute to GBM progression by promoting angiogenesis and glioma cell prolif...
ORGANISM(S): Homo Sapiens 
2024-05-07 | PXD045057 | panorama
TranscriptomicsGATA3 Reprograms Basal Breast Cancer Cells towards a Luminal Subtype and Inhibits Metastases through Suppression of Lysyl Oxidase
The transcription factor GATA3 is essential for luminal cell differentiation during mammary gland development and critical for formation of the luminal subtypes of breast cancer. Ectopic expression of GATA3 promoted global alterations of the transcriptome of basal triple-negative breast cancer cells...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-24249 | biostudies-arrayexpress
TranscriptomicsHK_CIA_experiment
In previous studies, we identified the fungal macrocyclic lactone (S)-curvularin (SC) as an anti-inflammatory agent using a screening system detecting inhibitors of the Janus kinase/signal transducer and activator of transcription pathway. The objective of the present study was to investigate whethe...
ORGANISM(S): Mus musculus 
2012-09-21 | E-MEXP-3180 | biostudies-arrayexpress
UnknownSphingosine-1-Phosphate Receptor Subtype 1 (S1P1) Modulator IMMH001 Regulates Adjuvant- and Collagen-Induced Arthritis.
Not available
S-EPMC6761374 | biostudies-literature
TranscriptomicsSubtype-specific genomic alterations define new targets for soft tissue sarcoma therapy
This SuperSeries is composed of the following subset Series: GSE21122: Whole-transcript expression data for soft-tissue sarcoma tumors and control normal fat specimens GSE21123: Affymetrix SNP array data for soft tissue sarcoma samples Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-07-05 | E-GEOD-21124 | biostudies-arrayexpress
UnknownA serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype.
Not available
S-EPMC9006548 | biostudies-literature
ProteomicsProteomics of Yucatan minipig cartilages
Ten cartilages, including hyaline, fibrous, and elastic cartilages, were analyzed via LC-MS/MS bottom-up proteomics analysis.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-06-09 | PXD025482 | Pride
Cartilage Fibrocartilage Collagen Hyaline cartilage Collagen subtype Yucatan minipig 
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