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MetabolomicsCollagen induced arthritis in dba/1j mice associates with oxylipin changes in plasma
Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA). The purpose of this research was to study differences in oxylipin levels between a widely used collagen-induced arthritis (CI...
2015-11-04 | MTBLS243 | MetaboLights
TranscriptomicsTranscription profiling of DBA/1J mouse with collagen induced arthritis
Time course of collagen-induced arthritis in DBA/1J male mice, synchronized on day 28 with 10ug LPS
ORGANISM(S): Mus musculus 
2009-11-16 | E-TABM-661 | biostudies-arrayexpress
MetabolomicsMulti-omics integration reveals Yu-Xue-Bi tablets attenuate rheumatoid arthritis via metabolic reprogramming-mediated Piezo1 suppression

As a systemic chronic inflammatory disease, Rheumatoid arthritis (RA) is characterized by progressive inflammation, bone and cartilage destruction, leading to significant disability, reduced lifespan, and increased mortality. The clinical use of conventional medications including nonsteroidal ant...

2026-01-24 | MTBLS13760 | MetaboLights
TranscriptomicsGene expression profile of preclinical arthritis and its modulation by antigen-induced tolerance
During the course of adjuvant arthritis, maximal changes in gene expression were observed at the incubation phase. A major group of genes affected was related to immune activity. Tolerance induction by mycobacterial heat-shock protein 65 (Bhsp65), the disease-related antigen, caused upregulation of ...
ORGANISM(S): Rattus norvegicus 
2011-11-16 | E-GEOD-31314 | biostudies-arrayexpress
ProteomicsCollagen induced arthritis plasma proteomic analysis
The aim of the project is to analyze the plasma proteomic profile of an animal model of arthritis (Collagen Induced Arthritis; CIA) in response to different treatments. For this, plasma samples from mice under five different treatments were analyzed (N=6 per group): Vehicle, CIA, CIA + Δ9-THCA-A (20...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-18 | PXD015274 | Pride
Cia Swath Plasma Arthritis 
TranscriptomicsTranscription profiling of mouse knee joint synovium from different grades of inflammation in mouse collagen induced arthritis (CIA)
Knee joint synovium was used for gene expression analysis of mouse collagen induced arthritis (CIA). Synovium was prepared at day 30 after initial sensitization from: healthy controls, CIA animals with no, with mild, with moderate, or with severe joint inflammation. Each sample group is represente...
ORGANISM(S): Mus musculus 
2009-09-15 | E-GEOD-13071 | biostudies-arrayexpress
ProteomicsPeriodontal pathogens do not exacerbate macroscopic arthritis but alter the synovial proteome
Rheumatoid arthritis (RA) and periodontitis (PD) are chronic inflammatory diseases that appear to occur in tandem. Autoantibodies against citrullinated peptide antigens linked pathogeneses with PD preceding RA. However, the mutual impact PD exerts on RA and vice versa has not yet been defined. To ad...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-04 | PXD020397 | Pride
Collagen-induced arthritis Hdmse Mus musculus Rheumatoid arthritis Synovial membrane Periodontitis 
ProteomicsProtein expression of Isolated B cells from splenocytes in collagen-induced arthritis (CIA) model between Wildtype (C57BL/6) and Stinggt/gt mice.
The pathogenesis of rheumatoid arthritis (RA) is complicated and involves both innate and adaptive immunity [5]. The innate immunity such as macrophages or fibroblast-like synoviocytes (FLS) in the synovium can generate inflammatory mediators, including TNF-α, IL-1, IL-6, IL-17, IFN-γ, and chemo kin...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-26 | PXD018652 | Pride
Quantitative proteomics Sting Collagen-induced arthritis 
TranscriptomicsExpression data from mouse arthritis tarsal joints
Pathological bone changes differ considerably between inflammatory arthritic diseases, and most studies have focused on bone erosion. Collagen Induced Arthritis (CIA) is a model for Rheumatoid Arthritis, which, in addition to bone erosion, demonstrates bone formation at the time for clinical manifes...
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-61140 | biostudies-arrayexpress
TranscriptomicsG-CSF receptor targeting in inflammatory arthritis
G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. We developed a neutralizing monoclonal antibody to the murine G-CSF receptor (G-CSFR), which antagonizes binding of murine G-CSF and inhibits G-CSFR signallin...
ORGANISM(S): Mus musculus 
2016-01-19 | E-GEOD-76966 | biostudies-arrayexpress
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