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MetabolomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma

Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumor suppressor genes (TSGs) and high tumor heterogeneity, including diverse metabolic adaptations. ...

2025-07-07 | MTBLS12461 | MetaboLights
ProteomicsA compendium of co-regulated protein complexes in breast cancer reveals collateral loss events
Protein complexes are responsible for the bulk of activities within the cell, but how their behavior and abundance varies across tumors remains poorly understood. By combining proteomic profiles of breast tumors with a large-scale protein-protein interaction network, we have identified a set of 285 ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-01 | PXD007543 | Pride
Breast cancer Collateral loss Protein-protein interaction Protein complex 
UnknownA Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.
Not available
S-EPMC5660599 | biostudies-literature
GenomicsMutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells
Development of resistance to targeted therapies has tempered initial optimism that precision oncology would improve poor outcomes for cancer patients. Resistance mechanisms, however, can also confer new resistance-specific vulnerabilities, termed collateral sensitivities. Here we investigated ALK in...
EGAS00001005791 | EGA
GenomicsKRASG12C inhibition produces a driver-limited state revealing collateral dependencies
KRASG12C inhibition produces a driver-limited state revealing collateral dependencies
PRJNA540780 | ENA
UnknownSex Differences in the Cerebral Collateral Circulation.
Not available
S-EPMC5429998 | biostudies-literature
UnknownCollateral bystander damage by myelin-directed CD8+ T cells causes axonal loss.
Not available
S-EPMC2731134 | biostudies-literature
UnknownRepurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic <i>RB1-NUDT15</i> Loss.
Not available
S-EPMC12402595 | biostudies-literature
UnknownTie2-Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke.
Not available
S-EPMC12806518 | biostudies-literature
UnknownAging causes collateral rarefaction and increased severity of ischemic injury in multiple tissues.
Not available
S-EPMC3141082 | biostudies-literature
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