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TranscriptomicsStructural and functional characterization of the N-terminus of Schizosaccharomyces pombe Cwf10
The spliceosome is a dynamic macromolecular machine that catalyzes the removal of introns from pre-mRNA to make mature message. Schizosaccharomyces pombe Cwf10 (homolog Saccharomyces cerevisiae Snu114 and of Human U5-116K), an integral member of the U5 snRNP, is a GTPase that shares sequence homolog...
ORGANISM(S): Schizosaccharomyces pombe 
2013-09-25 | E-GEOD-47573 | biostudies-arrayexpress
TranscriptomicsTime Course of Gene Expression in the Substantia Nigra in Response to Intrastriatal 6-hydroxydopamine in the rat.
The 6-hydroxydopamine (6OHDA) rat model of parkinsonism is among the first, and most commonly used, animal models of Parkinson’s disease. It provides insight into the compensatory changes that occur in the brain after dopamine (DA) neuron degeneration. In order to better define the consequences of s...
ORGANISM(S): Rattus norvegicus 
2014-06-21 | E-GEOD-58710 | biostudies-arrayexpress
UnknownEffect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency.
Not available
S-EPMC6870192 | biostudies-literature
TranscriptomicsInhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities, but not Inflammation and Injury in Mice
Abnormalities in hepatic lipid metabolism are believed to play a critical role in the etiology of nonalcoholic steatohepatitis (NASH). Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol (TAG) sy...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-60349 | biostudies-arrayexpress
ProteomicsAMpylation is a hallmark of human neuronal differentiation
The AMPylation is novel protein post-translation modification. In consist of attachment of the adenosine monophosphate onto the serine, threonine or tyrosine amino acid residues of the protein. This process is catalysed by bacterial effectors or in human by protein FICD (also called HYPE) which cont...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD008394 | Pride
Chemical-proteomics Cerebral organoids. Phosphoramidate prodrugs Ficd Ampylation Neuronal development 
UnknownEpilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency - molecular profiling and functional rescue.
Not available
S-EPMC5427847 | biostudies-literature
MetabolomicsLipid biomarkers for algal resistance to viral infection in the ocean

Marine viruses play a key role in regulating phytoplankton populations, greatly affecting the biogeochemical cycling of major nutrients in the ocean. Resistance to viral infection has been reported for various phytoplankton species under laboratory conditions. Nevertheless, the occurrence of resi...

2023-06-12 | MTBLS3323 | MetaboLights
UnknownExpression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia.
Not available
S-EPMC4930128 | biostudies-literature
UnknownLinkage of Wolfram syndrome to chromosome 4p16.1 and evidence for heterogeneity.
Not available
S-EPMC1914816 | biostudies-literature
UnknownBenchmarking causal reasoning algorithms for gene expression-based compound mechanism of action analysis.
Not available
S-EPMC10111792 | biostudies-literature
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