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GenomicsIdentification of a bile acid-binding transcription factor in Clostridioides difficile using chemical proteomics
Identification of a bile acid-binding transcription factor in Clostridioides difficile using chemical proteomics
PRJNA844117 | ENA
UnknownA chemical proteomics approach for global analysis of lysine monomethylome profiling.
Not available
S-EPMC4350029 | biostudies-literature
ProteomicsChemical proteomics of RID substrates
To globally profile the fatty-acylation substrate proteins of RID, we utilized the bioorthogonal chemical reporter Alk-16, an alkynyl-functionalized fatty acid analogue, to metabolically label fatty-acylated proteins in living cells. To identify the substrate proteins of RID, we sought to perform qu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD046500 | Pride
Rid Chemical proteomics 
UnknownTracking Pathogen Infections by Time-Resolved Chemical Proteomics.
Not available
S-EPMC8276254 | biostudies-literature
ProteomicsChemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors
Protein kinases are key components in signal transduction pathways and are established drug targets in oncology. Consequently, small molecule kinase inhibitors are on the rise but often show a rather broad target spectrum, potentially leading to toxic side effects. As a result, a broad assessment of...
ORGANISM(S): Homo sapiens (Human) 
2017-03-22 | PXD003373 | Pride
Kinase inhibitor Fech Photosensitivity Chemical proteomics Ferrochelatase Vemurafenib Kinobeads 
ProteomicsQuantitative chemical proteomics profile target proteins of ITCs
Quantitative chemical proteomics was performed to profile the target proteins of ITCs.For the forward SILAC experiment, heavy-labeled cells were treated with the ITC probe (20 μM) for 30 min and light-labeled cells were pre-treated with the natural ITC (60 μM) for 30 min, followed by the ITC probe (...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051941 | Pride
Human Silac Chemical proteomics Isothiocyanates Hf-x 
ProteomicsKetone Bodies-mediated Cysteine Modifications Discovered by Chemical Proteomics
All the studies of ketone body-dependent post-translational modifications (PTMs), notably those mediated by ketone bodies, β-hydroxybutyrate (Bhb) and acetoacetate (Acac), have focused on lysine acylations. However, given the chemically diverse and reactive nature of metabolites generated, it remain...
ORGANISM(S): Homo Sapiens 
PXD066371 |
ProteomicsCompetition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane’s targets and identify over 500 targets along with their relative affiniti...
ORGANISM(S): Homo sapiens (Human) 
2017-05-24 | PXD006279 | Pride
Sulforaphane  cancer  chemical proteomics 
UnknownDeconstructing Lipid Kinase Inhibitors by Chemical Proteomics.
Not available
S-EPMC5771882 | biostudies-literature
TranscriptomicsIdentification of a bile acid-binding transcription factor in Clostridioides difficile using chemical proteomics
Clostridioides difficile is a Gram-positive anaerobic bacterium that is the leading cause of hospital-acquired gastroenteritis in the US. In the gut milieu, C. difficile encounters microbiota-derived bile acids capable of inhibiting its growth, which are thought to be a mechanism of colonization res...
ORGANISM(S): Clostridioides difficile 
2022-06-03 | GSE205226 | GEO
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