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GenomicsSilencing ferrochelatase in breast cancer cells MDA-MB-231
Silencing ferrochelatase in breast cancer cells MDA-MB-231
PRJNA560254 | ENA
ProteomicsChemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors
Protein kinases are key components in signal transduction pathways and are established drug targets in oncology. Consequently, small molecule kinase inhibitors are on the rise but often show a rather broad target spectrum, potentially leading to toxic side effects. As a result, a broad assessment of...
ORGANISM(S): Homo sapiens (Human) 
2017-03-22 | PXD003373 | Pride
Kinase inhibitor Fech Photosensitivity Chemical proteomics Ferrochelatase Vemurafenib Kinobeads 
UnknownSubstrate interactions with human ferrochelatase.
Not available
S-EPMC1794275 | biostudies-literature
TranscriptomicsSilencing ferrochelatase in breast cancer cells MDA-MB-231
Aim was to identify novel targets of protoporphyrin-IX (PpIX) after silencing Ferrochelatase (FECH) enzyme. PpIX is a light sensitive metabolite of heme synthesis. Generation of PpIX is increased if FECH activity is suppressed. Here, silencing of FECH leads to down-regulation of PpIX, measured by a ...
ORGANISM(S): Homo sapiens 
2019-08-15 | GSE135845 | GEO
UnknownYeast frataxin solution structure, iron binding, and ferrochelatase interaction.
Not available
S-EPMC2859087 | biostudies-literature
UnknownFerrochelatase: Mapping the Intersection of Iron and Porphyrin Metabolism in the Mitochondria.
Not available
S-EPMC9133952 | biostudies-literature
UnknownPorphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme.
Not available
S-EPMC1134880 | biostudies-literature
UnknownProduct release rather than chelation determines metal specificity for ferrochelatase.
Not available
S-EPMC2771925 | biostudies-literature
UnknownMetal ion substrate inhibition of ferrochelatase.
Not available
S-EPMC3259753 | biostudies-literature
UnknownRed cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.
Not available
S-EPMC4296013 | biostudies-literature
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