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ProteomicsAP-SWATH analysis reveals a direct involvement of VCP/p97 in integrated stress response signalling through CReP/PPP1R15B degradation
The ubiquitin-directed AAA-ATPase VCP/p97 facilitates degradation of misfolded proteins in diverse cellular stress response pathways. Resolving the complexity of dynamic interactions with hosts of accessory proteins and substrates has therefore been a major challenge. Here, we used affinity-purifica...
ORGANISM(S): Homo sapiens (Human) 
2018-04-04 | PXD007876 | Pride
Integrated stress response Ap-swath P97 
TranscriptomicsTranscription profiling of mouse E8.5 wild-type and 3 E8.5 Tcof1+/- littermate embryos (Treacher Collins Syndrome)
The object of this study was to identify genes transcriptionally upregulated and downregulated in response to Tcof1 haploin-sufficiency during mouse embryogensis Experiment Overall Design: Total RNA was extracted from 3 E8.5 wild-type and 3 E8.5 Tcof1+/- littermate embryos using the RNeasy Mini Pro...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10167 | biostudies-arrayexpress
UnknownOral citrate supplementation mitigates age-associated pathological intervertebral disc calcification in LG/J mice.
Not available
S-EPMC11275755 | biostudies-literature
UnknownOral Citrate Supplementation Mitigates Age-Associated Pathologic Intervertebral Disc Calcification in LG/J Mice.
Not available
S-EPMC12073913 | biostudies-literature
UnknownStudies on the biosynthesis of the notoamides: synthesis of an isotopomer of 6-hydroxydeoxybrevianamide E and biosynthetic incorporation into notoamide J.
Not available
S-EPMC3148199 | biostudies-literature
UnknownTreacher Collins syndrome.
Not available
S-EPMC3227269 | biostudies-literature
UnknownThe Fort Collins commuter study: Variability in personal exposure to air pollutants by microenvironment.
Not available
S-EPMC6435329 | biostudies-literature
ProteomicsIn vivo and in vitro proteome analysis of HIV-1 infected, human CD4+ T cells
Host directed therapies against HIV-1 are thought to be critical for long term containment of the HIV-1 pandemic but remain elusive. Since HIV-1 infects and manipulates important effectors of both the innate and adaptive immune system, identifying modulations of the host cell systems in humans durin...
ORGANISM(S): Homo sapiens (Human) 
2017-02-28 | PXD005234 | Pride
Cd4 t cell Hiv Swath 
UnknownLarge deletions encompassing the TCOF1 and CAMK2A genes are responsible for Treacher Collins syndrome with intellectual disability.
Not available
S-EPMC3865420 | biostudies-literature
TranscriptomicsInterstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.
Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and developed countries. In humans, genetic factors greatly influence individual susceptibility to NAFLD. The goals of this study were to compare the magnitude of inte...
ORGANISM(S): Mus musculus 
2014-10-16 | E-GEOD-62362 | biostudies-arrayexpress
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