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MetabolomicsScreening of Differential Metabolites and Metabolic Pathway Analysis Related to Colorectal Adenoma Recurrence

Background To analyze the differences in gut metabolites between the CRA (colorectal adenoma) recurrence and non-recurrence groups, to identify characteristic metabolites and related metabolic pathways associated with recurrence, and to provide new evidence for risk stratification and interv...

2026-08-08 | MTBLS15298 | MetaboLights
MetabolomicsMetabolomic Profiling of Veillonella parvula Reveals Metabolites Associated with Colorectal Adenoma Progression
An untargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based metabolomics analysis was performed to characterize metabolites produced during the cultivation of Veillonella parvula. Culture supernatants collected from V. parvula cultures were compared with uninoculated culture-medium...
2026-08-21 | MTBLS15238 | MetaboLights
TranscriptomicsComplex Patterns of Altered MicroRNA Expression during the Adenoma-Adenocarcinoma Sequence for Microsatellite-stable Colorectal Cancer
We searched the database of the Department of Pathology at The University of Texas MD Anderson Cancer Center and selected 21 patients who had invasive microsatellite-stable colorectal adenocarcinoma arising from a pre-existing adenoma and adjacent non-neoplastic mucosa in a resection specimen to per...
ORGANISM(S): Homo sapiens 
2012-08-17 | E-MTAB-813 | biostudies-arrayexpress
ProteomicsProteome Landscapes of the Human Colorectal Mucosa, and its Adenoma and Cancer
Adenomatous polyps in the colorectal tract are benign tumors with the potential to develop cancer. In this study we perform a large scale proteomic study of comparing the proteomes of colorectal enterocytes (N) and the cells of the adenoma (A) and cancer (C). Using formalin fixed and paraffin embedd...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-10 | MSV000080620 | MassIVE
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
TranscriptomicsWhole-exome sequencing (WES) to assess genomic concordance between an adenoma/adenocarcinoma colonoid culture 14-881 and the source patient tissue
A patient-derived epithelium-only colon rectal organoid, also referred to as a colonoid, was generated from an adenoma (associated with a resection surgery of an invasive moderately differentiated colorectal adenocarcinoma) as part of the development of an on-going organoid biobank at the Michigan M...
ORGANISM(S): Homo sapiens 
2020-12-22 | E-MTAB-9936 | biostudies-arrayexpress
TranscriptomicsMultiple genes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression
Chromosomal instability (CIN) is the hallmark of colorectal adenoma to carcinoma progression in 85% of cases, with 20q gain as the most prominent aberration. Yet, the oncogenes at this chromosomal gain are still largely unknown. Here, we aimed to identify oncogenes at 20q involved in colorectal aden...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-8067 | biostudies-arrayexpress
TranscriptomicsRNA-seq of LGR5(+) and LGR5(-) cells isolated from human colon adenoma organoids and targeted DNA-seq of a colorectal biobank
This study has two components: (1) Human colon adenoma organoids (n=4 patients) were dissociated into single cells. Cells were incubated with a magnetic bead bound to an LGR5 antibody and run through a magnetic column. Magnet bound cells and flow through negative (FTN) cells were obtained. Magnet bo...
ORGANISM(S): Homo sapiens 
2020-04-30 | E-MTAB-4698 | biostudies-arrayexpress
TranscriptomicsGlobal DNA methylation alterations reveal multiple pathways in the initiation and progression of colorectal cancer
Genetic and epigenetic alterations are a fundamental aspect of colorectal cancer formation. There is considerable heterogeneity between colorectal cancers regarding the mutations and methylated genes they carry, and this heterogeneity may arise early in the polyp-cancer sequence. However, our unde...
ORGANISM(S): Homo sapiens 
2014-09-08 | E-GEOD-48684 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of adenoma and corresponding normal mucosa in human colorectal cancer cases
The differences in gene expression profile between adenoma and corresponding normal mucosa in colorectal cancer cases.
ORGANISM(S): Homo sapiens 
2005-05-20 | E-MEXP-341 | biostudies-arrayexpress
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