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ProteomicsPathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples
Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-08-25 | MSV000080100 | MassIVE
Proteomics5HT - Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3
we provide evidence for a new class of histone posttranslational modification (PTM): serotonylation.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-04 | MSV000093567 | MassIVE
GenomicsH3K36ac is an evolutionary conserved histone modification that marks active genes in plants
In eukaryotic cells, DNA is tightly packed in the nucleus in chromatin which has histones as its main protein component. Histones are subject to a large number of distinct post-translational modifications, whose sequential or combinatorial action affects genome function. Here, we report the identifi...
ORGANISM(S): Arabidopsis thaliana 
2016-04-05 | E-GEOD-74841 | biostudies-arrayexpress
ProteomicsTrypanosoma brucei histones are heavily modified with combinatorial post-translational modifications and mark Pol II transcription start regions with hyperacetylated H2A.
Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and display some unusual genomic and epigenetic properties that provide valuable insight into the early processes employed by eukaryotic ancestors to regulate chromatin-mediated functions. We sequenced Trypanosoma br...
ORGANISM(S): Trypanosoma brucei 
2022-08-21 | PXD024574 | Pride
Combinatorial histone post-translational modification Transcription Epigenetics Trypanosoma brucei Histone hyperacetylation 
ProteomicsA dynamic and combinatorial histone code drives malaria parasite asexual and sexual development
Histone post-translational modifications (PTMs) are frequently co-occurring on the same chromatin domains or even the same molecule. It is now established that these ‘histone codes’ are the result of cross-talk between enzymes that catalyse multiple PTMs with univocal readout as compared to these PT...
ORGANISM(S): Plasmodium falciparum V1 
2022-05-19 | PXD030181 | Pride
Malaria Middle-down mass spectrometry proteomics Post-translational modification Parasite Ptm Gametocyte Histone code Plasmodium falciparum 
ProteomicsSystems level analysis of histone H3 post-translational modifications reveals features of PTM crosstalk in chromatin regulation
Chromatin structure and function is maintained by dynamic protein-protein and protein-nucleic acid interactions. Histones are a family of proteins that are abundant chromatin constituents and that carry numerous post-translational modifications (PTMs). Histone PTMs mediate a variety of biological ac...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-16 | PXD002560 | Pride
Post-translational modification  crosstalk  histone  mass spectrometry  proteomics 
ProteomicsPathology tissue-quantitative mass spectrometry analysis to profile histone post-translational modification patterns in patient samples
Histone post-translational modifications (hPTMs) generate a complex combinatorial code that has been implicated with various pathologies, including cancer. Dissecting such a code in physiological and diseased states may be exploited for epigenetic biomarker discovery, but hPTM analysis in clinical s...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-10-14 | PXD002669 | Pride
Biomarker  epigenetics  ffpe  super-silac  cancer 
UnknownHistone H3 Thr 45 phosphorylation is a replication-associated post-translational modification in S. cerevisiae.
Not available
S-EPMC2856316 | biostudies-literature
ProteomicsTop Down Histone H4 - SUM159 Butyrate
Proteins physiologically exist and function as ‘proteoforms’ that arise from one gene but acquire additional function by further variation such as post-translational modification (PTM). When multiple PTMs coexist on single protein molecules top down proteomics becomes the only feasible method; howev...
ORGANISM(S): Homo sapiens (Human) 
2019-11-22 | PXD013766 | Pride
Top-down Histone h4 
ProteomicshSWATH: Unlocking SWATH’s full potential for an untargeted histone perspective
Mass spectrometry (MS) has become the technique of choice for large-scale analysis of histone post-translational modifications (hPTMs) and their combinatorial patterns, especially in untargeted settings where novel discovery-driven hypotheses are being generated. However, MS-based histone analysis r...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2019-08-27 | PXD011198 | Pride
Sequential window acquisition of all theoretical fragment ion spectra (swath)  data independent acquisition (dia)  histone  mass spectrometry (ms)  post-translational modification (ptm)  epigenetics 
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